Table 3 Multivariable Cox proportional hazards model

HR⁺ vs. HR^-

0.63 (0.46 to 0.86)

0.003

0.51 (0.34 to 0.79)

0.002

HER-2 amplified/overexpressed vs. HER-2 normal

0.52 (0.34 to 0.79)

0.002

0.39 (0.21 to 0.73)

0.003

Visceral vs. other metastases

1.39 (0.92 to 2.05)

0.095

1.77 (0.95 to 3.30)

0.074

Number of metastatic sites (1 vs. 3 vs. ≥ 3)

0.88 (0.70 to 1.10)

0.266

0.67 (0.47 to 0.95)

0.024

Circulating tumor cells (< 5 versus ≥ 5)

0.58 (0.43 to 0.79)

< 0.001

0.40 (0.26 to 0.62)

< 0.001