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Table 2 Treatment administered

From: Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment

Treatment

Age (years)

Overall

CTC < 5

CTC ≥ 5

Endocrine treatment

56 (36 to 82)

47 (20.0)

33 (70.2)

14 (29.8)

   Aromatase inhibitor

 

35 (74.5)

25 (71.4)

10 (28.6)

   Tamoxifen

 

8 (17.0)

6 (75.0)

2 (25.0)

   Fulvestrant

 

4 (8.5)

2 (50.0)

2 (50.0)

Monochemotherapy

57 (31 to 81)

45 (19.1)

23 (51.1)

22 (48.9)

   Taxane

 

21 (46.7)

12 (57.1)

9 (42.9)

   Othera

 

24 (53.3)

11 (45.8)

13 (54.2)

Combination chemotherapy

53 (23 to 78)

64 (27.2)

40 (62.5)

24 (37.5)

   Taxane + anthracycline

 

25 (39.1)

16 (64.0)

9 (36.0)

   Taxane + capecitabine

 

22 (34.4)

13 (59.1)

9 (40.9)

   Taxane + other cytotoxic agentb

 

7 (10.9)

5 (71.4)

2 (28.6)

   Otherc

 

10 (15.6)

6 (60.0)

4 (40.0)

Chemotherapy + anti-HER2 drugs

53 (28 to 81)

40 (17.0)

26 (65.0)

14 (35.0)

   Chemotherapy + trastuzumabd

 

30 (75.0)

17 (57)

13 (43)

   Chemotherapy + lapatinib

 

10 (25.0)

9 (90)

1 (10)

Chemotherapy + bevacizumab

49 (30 to 67)

39 (16.6)

19 (48.7)

20 (51.3)

   Monochemotherapy + bevacizumab

 

32 (82.1)

18 (56.2)

14 (43.8)

   Polychemotherapy + bevacizumab

 

7 (17.9)

1 (14.3)

6 (85.7)

  1. Data presented as n (%) or median (range). CTC, circulating tumor cell; HER-2, human epidermal growth factor receptor-2. aCapecitabine (n = 17), epirubicin (n = 1), vinorelbine (n = 1), gemcitabine (n = 3), carboplatin (n = 2). bTaxane + carboplatin (n = 6), taxane + gemcitabine (n = 1). c5-Fluorouracil + epirubicin + cyclophosphamid (n = 5), fluorouracil + doxorubicin + cyclophosphamid (n = 2), gemcitabine + carboplatin (n = 3). dTaxane-based chemotherapy + trastuzumab (n = 24).