Luminal-B breast cancer and novel therapeutic targets

Breast Cancer Research

Table 3 Pathological complete response rates post neoadjuvant chemotherapy in molecular subtypes of breast cancer

				Pathological complete response rate (%)
Author	n	Method of molecular classification	Defining luminal B	Luminal A	Luminal B	HER2-positive	Basal-like
Esserman and colleagues [25]	144	Microarray	Intrinsic gene set and hierarchical clustering (included some HER2⁺)	-5	13	55	34
De Ronde and colleagues [26]	191	Microarray	Intrinsic gene set and hierarchical clustering (included some HER2⁺)	7	7	44	44
Bhargava and colleagues [27]	359	IHC surrogate markers	ER^-, HER2^-	2	1	33	30
Carey and colleagues [28]	107	IHC surrogate markers	ER⁺, HER2⁺	0	15	36	27
Rouzier and colleagues [29]	82	Microarray	Intrinsic gene set and hierarchical clustering (included some HER2⁺)	7^a	7^a	45	45

ER, estrogen receptor; IHC, immunohistochemistry. ^aIn Rouzier and colleagues [29], luminal-A and luminal-B subtypes were grouped together as the luminal subtype.

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