Table 2 Risk of early versus late relapse in molecular subtypes of breast cancer
|  | Early (<5 years) distant metastases (n= 831) | Late (≥5 years) distant metastases (n= 652) | ||||
|---|---|---|---|---|---|---|
| Â | HR | 95% CI | Pvalue | HR | 95% CI | Pvalue |
Age | Â | Â | Â | Â | Â | Â |
   (<50 years vs. ≥50 years) | 0.77 | (0.56, 1.06) | NS | 1.65 | (0.97, 2.81) | NS |
Tumor size | Â | Â | Â | Â | Â | Â |
   (≤2 cm vs. >2 cm) | 1.31 | (0.91, 1.86) | NS | 1.18 | (0.69, 2.01) | NS |
Histological grade | Â | Â | Â | Â | Â | Â |
   (2 vs. 1) | 5.02 | (1.80, 14.0) | <0.01 | 0.92 | (0.48, 1.76) | NS |
   (3 vs. 1) | 7.22 | (2.59, 20.2) | <0.01 | 0.70 | (0.31, 1.60) | NS |
Molecular subtype | Â | Â | Â | Â | Â | Â |
   Luminal-A | 1 | - | - | 1 | - | - |
   Luminal-B | 2.86 | (1.70, 4.80) | <0.01 | 0.65 | (0.24, 1.72) | NS |
   HER2-positive | 2.62 | (1.50, 4.60) | <0.01 | 1.41 | (0.64, 3.12) | NS |
   Basal-like | 2.83 | (1.92, 4.82) | <0.01 | 0.96 | (0.54, 1.70) | NS |