Table 1 Luminal-B breast cancer

Genes overexpressed in gene expression profiling

   ER and ER-regulated genes

   Proliferation-related genes

   Cell cycle genes

Histopathological features

   ER-positive

   High grade

   High Ki-67

Clinical features

   Poorer disease-free survival

   Increased risk of early relapse

   Predisposition to relapse in bone and pleura

   Relative insensitivity to endocrine therapy compared with luminal-A subtype

   Relative insensitivity to chemotherapy compared with basal-like and HER2-positive subtypes