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Table 1 Luminal-B breast cancer

From: Luminal-B breast cancer and novel therapeutic targets

Genes overexpressed in gene expression profiling
   ER and ER-regulated genes
   Proliferation-related genes
   Cell cycle genes
Histopathological features
   ER-positive
   High grade
   High Ki-67
Clinical features
   Poorer disease-free survival
   Increased risk of early relapse
   Predisposition to relapse in bone and pleura
   Relative insensitivity to endocrine therapy compared with luminal-A subtype
   Relative insensitivity to chemotherapy compared with basal-like and HER2-positive subtypes
  1. ER, estrogen receptor.