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Table 2 Age-adjusted and fully adjusted relative hazards of breast cancer mortality and other-cause mortality among breast cancer patients ages 66 years and older, SEER-Medicare data from 1992 to 2000a

From: Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study

 

Breast cancer deaths

Other-cause deaths

Characteristics

Age-adjusted model

Fully adjusted modelb

Age-adjusted model

Fully adjusted modelb

Age, years

Crude

 

Crude

 

   66 to 74

Reference

Reference

Reference

Reference

   75 to 84

1.21 (1.16 to 1.27)

1.20 (1.14 to 1.26)

2.28 (2.21 to 2.34)

2.04 (1.98 to 2.10)

   85+

2.23 (2.10 to 2.36)

1.67 (1.57 to 1.78)

6.08 (5.86 to 6.31)

4.63 (4.46 to 4.82)

Race/ethnicity

    

   White

Reference

Reference

Reference

Reference

   Black

1.79 (1.67 to 1.92)

1.12 (1.05 to 1.21)

1.29 (1.23 to 1.36)

1.05 (0.99 to 1.10)

   Hispanic

1.21 (1.08 to 1.35)

0.96 (0.86 to 1.08)

0.97 (0.89 to 1.05)

0.87 (0.81 to 0.95)

   Other/unknown

0.73 (0.64 to 0.83)

0.76 (0.66 to 0.87)

0.75 (0.68 to 0.81)

0.73 (0.67 to 0.80)

Stage

    

   I

Reference

Reference

Reference

Reference

   II

3.72 (3.51 to 3.94)

3.05 (2.88 to 3.24)

1.26 (1.23 to 1.30)

1.24 (1.20 to 1.27)

   III and IV

19.9 (18.8 to 21.1)

11.50 (10.8 to 12.3)

1.76 (1.67 to 1.85)

1.65 (1.56 to 1.74)

   Unknown

5.38 (4.98 to 5.81)

2.88 (2.64 to 3.13)

1.37 (1.30 to 1.44)

1.03 (0.97 to 1.09)

Grade

    

   1

Reference

Reference

Reference

Reference

   2

2.45 (2.22 to 2.70)

1.76 (1.60 to 1.94)

1.07 (1.03 to 1.11)

1.04 (1.00 to 1.08)

   3 and 4

5.64 (5.14 to 6.20)

2.63 (2.39 to 2.90)

1.18 (1.13 to 1.23)

1.09 (1.05 to 1.14)

   Unknown

4.34 (3.94 to 4.78)

1.93 (1.75 to 2.13)

1.21 (1.16 to 1.27)

1.06 (1.01 to 1.11)

ER status

    

   Positive

Reference

Reference

Reference

Reference

   Negative

2.48 (2.35 to 2.61)

1.71 (1.62 to 1.81)

1.05 (1.01 to 1.10)

1.03 (0.99 to 1.08)

   Unknown/other

1.78 (1.70 to 1.87)

1.24 (1.18 to 1.31)

1.22 (1.18 to 1.26)

1.08 (1.05 to 1.12)

Comorbidity

    

   None

Reference

Reference

Reference

Reference

   Previous cancer

1.10 (1.03 to 1.16)

1.20 (1.13 to 1.26)

1.68 (1.63 to 1.74)

1.29 (1.25 to 1.34)

   Cardiovascular disease

1.44 (1.36 to 1.53)

1.24 (1.17 to 1.32)

2.83 (2.73 to 2.94)

1.87 (1.80 to 1.93)

   COPD

1.20 (1.12 to 1.30)

1.13 (1.05 to 1.22)

2.66 (2.56 to 2.78)

1.71 (1.65 to 1.78)

   Diabetes

1.31 (1.24 to 1.40)

1.10 (1.03 to 1.16)

2.37 (2.28 to 2.46)

1.57 (1.52 to 1.63)

  1. aSEER: Surveillance, Epidemiology and End Results; ER: estrogen receptor; COPD: chronic obstructive pulmonary disease. bAdjusted for age, race/ethnicity, stage, grade, ER status, surgery, radiation, chemotherapy and all comorbidities. Data are expresses as relative hazards (95% confidence intervals).