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Figure 7 | Breast Cancer Research

Figure 7

From: Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

Figure 7

HIF-1α silencing inhibits the exaggerated hypoxia response in basal and subgroup 7 cancer cell lines. (A) Basal breast cancer cell line demonstrate higher HIF-1α mRNA levels when compared to luminal breast cancer cell lines (B) Basal breast cancer cell line demonstrate higher VEGF mRNA levels when compared to luminal breast cancer cell lines. (C, D) The silencing of HIF-1α but not EPAS1 (HIF-2α mRNA by siRNA inhibits hypoxia-induced gene expression (VEGF) levels in basal breast cancer cell lines (C) and HER2-basal subtypes cell lines (D) under both normal and hypoxic conditions as compared to their respective luminal-type breast cancer cell lines.

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Breast Cancer Research

ISSN: 1465-542X

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