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Figure 5 | Breast Cancer Research

Figure 5

From: Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

Figure 5

HER2 related tumors demonstrate a significant correlative relationship between basal-like and hypoxia-related gene expression. A positive correlation between basal-like and hypoxia-related gene expression was observed in the tumors assigned to subgroups 7 (highlighted in red) and 10 (highlighted in blue) in the (A) primary (n = 112, P <0.0001) and (F) validation (n = 84, P <0.0001) datasets; in tumors classified as ERBB2+ by the intrinsic gene list in the (B) primary (n = 115, P <0.0001) and (G) validation (n = 54, P = 0.0012) datasets; and in tumors that are HER2+ by IHC in the (C) primary (n = 49, P <0.0001) and (H) validation (n = 33, P = 0.0069) datasets. HIF-1α mRNA expression in IHC HER2+ tumors correlates with hypoxia-related gene expression in the (D) primary (n = 49, P = 0.0256) and (I) validation (n = 33, P = 0.0032) datasets. EPAS1 (HIF-2α) mRNA expression in IHC HER2+ tumors correlates with hypoxia-related gene expression in the (E) primary (n = 49, P = 0.0038) and (J) validation (n = 33, P = 0.0094) datasets.

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