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Table 1 Baseline characteristics of breast cancer patients by plasma levels of C-reactive protein

From: Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study

  Tertiles of C-reactive protein (mg/L)  
  1st (<1.04) 2nd (1.04 to 3.24) 3rd (>3.24) P
No. of patients 975 966 969  
Median age, years (IQR) 59 (48 to 68) 64 (55 to 73) 65 (56 to 74) <0.001
Tumour size, No. (%)     
   ≤20 mm 587 (60) 487 (50) 427 (44)  
   20 to 50 mm 297 (30) 377 (39) 384 (40)  
   >50 mm 25 (3) 31 (3) 47 (5) <0.001
   Unknown 66 (7) 71 (7) 111 (11)  
Lymph node status, No. (%)     
   Lymph node negative 459 (47) 453 (47) 442 (44)  
   Lymph node positive 451 (46) 443 (46) 441 (46) 0.74
   Unknown 65 (7) 70 (7) 106 (11)  
Distant metastases, No. (%)     
   No 942 (97) 929 (96) 909 (94)  
   Yes 6 (1) 7 (1) 27 (3) <0.001
   Unknown 27 (3) 30 (3) 33 (3)  
Tumour grade, No. (%)     
   Well differentiated 248 (25) 243 (25) 194 (20)  
   Moderately differentiated 431 (44) 392 (41) 439 (45)  
   Poorly/un-differentiated 158 (16) 193 (20) 154 (16) 0.006
   Unknown 138 (14) 138 (14) 182 (19)  
Estrogen receptor status, No. (%)     
   Positive 766 (79) 744 (77) 723 (75)  
   Negative 146 (15) 150 (16) 140 (14) 0.90
   Unknown 63 (6) 72 (7) 106 (11)  
Progesterone receptor status, No. (%)     
   Positive 492 (50) 451 (47) 440 (45)  
   Negative 243 (25) 286 (30) 258 (27) 0.07
   Unknown 240 (25) 229 (24) 271 (28)  
HER2 status, No. (%)     
   Positive 279 (29) 260 (27) 268 (28)  
   Negative 82 (8) 68 (7) 70 (7) 0.76
   Unknown 614 (63) 638 (66) 631 (65)  
Cigarettes smoked per day, No. (%)     
   <10 689 (71) 624 (65) 531 (55)  
   10 to 20 91 (9) 110 (11) 141 (15)  
   ≥20 61 (6) 80 (8) 110 (11) <0.001
   Unknown 134 (14) 152 (16) 187 (19)  
Alcohol consumption in grams per week*, No. (%)     
   ≤168 786 (81) 743 (77) 702 (72)  
   >168 66 (7) 82 (8) 86 (9) 0.08
   Unknown 123 (13) 141 (15) 181 (19)  
Body mass index in kg/m2†, No. (%)     
   <18.5 46 (5) 16 (2) 15 (2)  
   18.5 to 24.9 554 (57) 367 (38) 255 (26)  
   25 to 29.9 133 (14) 241 (25) 242 (25)  
   ≥30 18 (2) 75 (8) 138 (14) <0.001
   Unknown 224 (23) 267 (28) 319 (33)  
Menopause status, No (%)     
   Post menopause 640 (66) 795 (82) 825 (85)  
   Pre menopause 325 (33) 159 (16) 130 (13) <0.001
   Unknown 10 (1) 12 (1) 14 (1)  
Cardiovascular disease, No (%)     
   No 910 (93) 869 (90) 847 (87)  
   Yes 38 (4) 60 (6) 78 (8) <0.001
   Unknown 27 (3) 37 (4) 44 (5)  
  1. Blood samples were drawn and CRP measured at time of diagnosis of breast cancer.
  2. P-values were calculated using χ2 tests for categorical variables and Kruskal-Wallis one-way analysis of variance tests for continuous variables. For the evaluation of P-values, patients with unknown values were excluded.
  3. IQR = interquartile range.
  4. *Cut-off values are based on the recommendation from of the Danish National Board of Health.
  5. Body mass index was calculated as weight in kilograms divided by height in meters squared.