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Table 1 Molecular classification of breast carcinoma

From: Choosing the right cell line for breast cancer research

Classification Immunoprofile Other characteristics Example cell lines (adapted from [13, 22])
Luminal A ER+, PR+/-, HER2- Ki67 low, endocrine responsive, often chemotherapy responsive MCF-7, T47D, SUM185
Luminal B ER+, PR+/-, HER2+ Ki67 high, usually endocrine responsive, variable to chemotherapy. HER2+ are trastusumab responsive BT474, ZR-75
Basal ER-, PR-, HER2- EGFR+ and/or cytokeratin 5/6+, Ki67 high, endocrine nonresponsive, often chemotherapy responsive MDA-MB-468, SUM190
Claudin-low ER-, PR-, HER2- Ki67, E-cadherin, claudin-3, claudinin-4 and claudinin-7 low. Intermediate response to chemotherapy BT549, MDA-MB-231, Hs578T, SUM1315
HER2 ER-, PR-, HER2+ Ki67 high, trastusumab responsive, chemotherapy responsive SKBR3, MDA-MB-453
  1. EGFR, epidermal growth factor receptor; ER, oestrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor.