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Figure 4 | Breast Cancer Research

Figure 4

From: Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

Figure 4

Involvement of mitogen-activated protein kinase/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt in IGF-1R signal-mediated antiestrogen resistance of MCF7/IGF-1R cells. (a) Inhibitory effects of kinase inhibitors on IGF-1R autoactivation and its signaling transduction. (b) Inhibitory effects of kinase inhibitors on tamoxifen resistance of MCF7/IGF-1R cells in response to TAM (1 μM) individually or combined with E2 (1 nM) and IGF-1 (100 ng/mL) as indicated. (c) Inhibitory effects of kinase inhibitors on FUL resistance of MCF7/IGF-1R cells in response to FUL (1 μM) individually or combined with E2 (1 nM) and IGF-1 (100 ng/mL) as indicated. (-), no kinase inhibitor. SRB absorbance values are representative of three independent experiments. Error bars represent ± SD. ***P < 0.001.

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