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Table 4 Validation results in the German MARIE study

From: Coffee consumption modifies risk of estrogen-receptor negative breast cancer

Type of breast cancer Daily coffee consumption Controls/cases ORa(95% CI) ORb(95% CI)
All ≤ 1 cup 2,148/1,086 1.00 reference 1.00 reference
  > 1 to 3 cups 2,136/1,050 0.97 (0.88 to 1.08) 0.97 (0.87 to 1.07)
  > 3 to 5 cups 748/358 0.94 (0.82 to 1.09) 0.95 (0.82 to 1.10)
  > 5 cups 363/157 0.85 (0.70 to 1.04) 0.87 (0.71 to 1.07)
  P trend   0.128 0.173
ER-positive ≤ 1 cup 2,148/854 1.00 reference 1.00 reference
  > 1 to 3 cups 2,136/822 0.96 (0.86 to 1.08) 0.95 (0.85 to 1.07)
  > 3 to 5 cups 748/279 0.93 (0.79 to 1.09) 0.94 (0.80 to 1.10)
  > 5 cups 363/129 0.90 (0.72 to 1.12) 0.92 (0.74 to 1.15)
  P trend   0.221 0.302
ER-negative ≤ 1 cup 2,148/214 1.00 reference 1.00 reference
  > 1 to 3 cups 2,136/212 1.00 (0.82 to 1.22) 1.02 (0.83 to 1.24)
  > 3 to 5 cups 748/76 1.04 (0.79 to 1.36) 1.04 (0.78 to 1.37)
  > 5 cups 363/25 0.67 (0.44 to 1.03) 0.67 (0.43 to 1.05)
  P trend   0.288 0.326
PR-positive ≤ 1 cup 2,148/737 1.00 reference 1.00 reference
  > 1 to 3 cups 2,136/686 0.93 (0.83 to 1.05) 0.92 (0.82 to 1.04)
  > 3 to 5 cups 748/239 0.93 (0.78 to 1.10) 0.93 (0.78 to 1.10)
  > 5 cups 363/115 0.93 (0.74 to 1.17) 0.96 (0.76 to 1.20)
  P trend   0.299 0.363
PR-negative ≤ 1 cup 2,148/332 1.00 reference 1.00 reference
  > 1 to 3 cups 2,136/348 1.06 (0.90 to 1.24) 1.06 (0.90 to 1.25)
  > 3 to 5 cups 748/116 1.01 (0.80 to 1.26) 1.02 (0.81 to 1.28)
  > 5 cups 363/39 0.68 (0.48 to 0.97) 0.70 (0.49 to 1.00)
  P trend   0.194 0.280
  1. Multivariate-adjusted OR estimates and corresponding 95% CIs of postmenopausal breast cancer for coffee consumption in the German MARIE study, overall and stratified by breast cancer tumour subtype based on ER and PR status.
  2. aOdds ratio (OR) and corresponding 95% confidence intervals (CI) adjusted for matching factors age at enrolment in years (continuous) and study region.
  3. bOR and corresponding 95% CI adjusted for age at enrolment in years (continuous) and study region potential confounders (hormone replacement therapy (HRT, ever/never), ever smoked > 100 cigarettes, and education (low, medium, high) and average daily alcohol consumption (continuous, in g/day)).
  4. ER, estrogen receptor; PR, progesterone receptor.