Table 4 Validation results in the German MARIE study
From: Coffee consumption modifies risk of estrogen-receptor negative breast cancer
Type of breast cancer | Daily coffee consumption | Controls/cases | ORa(95% CI) | ORb(95% CI) |
|---|---|---|---|---|
All | ≤ 1 cup | 2,148/1,086 | 1.00 reference | 1.00 reference |
> 1 to 3 cups | 2,136/1,050 | 0.97 (0.88 to 1.08) | 0.97 (0.87 to 1.07) | |
> 3 to 5 cups | 748/358 | 0.94 (0.82 to 1.09) | 0.95 (0.82 to 1.10) | |
> 5 cups | 363/157 | 0.85 (0.70 to 1.04) | 0.87 (0.71 to 1.07) | |
P trend | 0.128 | 0.173 | ||
ER-positive | ≤ 1 cup | 2,148/854 | 1.00 reference | 1.00 reference |
> 1 to 3 cups | 2,136/822 | 0.96 (0.86 to 1.08) | 0.95 (0.85 to 1.07) | |
> 3 to 5 cups | 748/279 | 0.93 (0.79 to 1.09) | 0.94 (0.80 to 1.10) | |
> 5 cups | 363/129 | 0.90 (0.72 to 1.12) | 0.92 (0.74 to 1.15) | |
P trend | 0.221 | 0.302 | ||
ER-negative | ≤ 1 cup | 2,148/214 | 1.00 reference | 1.00 reference |
> 1 to 3 cups | 2,136/212 | 1.00 (0.82 to 1.22) | 1.02 (0.83 to 1.24) | |
> 3 to 5 cups | 748/76 | 1.04 (0.79 to 1.36) | 1.04 (0.78 to 1.37) | |
> 5 cups | 363/25 | 0.67 (0.44 to 1.03) | 0.67 (0.43 to 1.05) | |
P trend | 0.288 | 0.326 | ||
PR-positive | ≤ 1 cup | 2,148/737 | 1.00 reference | 1.00 reference |
> 1 to 3 cups | 2,136/686 | 0.93 (0.83 to 1.05) | 0.92 (0.82 to 1.04) | |
> 3 to 5 cups | 748/239 | 0.93 (0.78 to 1.10) | 0.93 (0.78 to 1.10) | |
> 5 cups | 363/115 | 0.93 (0.74 to 1.17) | 0.96 (0.76 to 1.20) | |
P trend | 0.299 | 0.363 | ||
PR-negative | ≤ 1 cup | 2,148/332 | 1.00 reference | 1.00 reference |
> 1 to 3 cups | 2,136/348 | 1.06 (0.90 to 1.24) | 1.06 (0.90 to 1.25) | |
> 3 to 5 cups | 748/116 | 1.01 (0.80 to 1.26) | 1.02 (0.81 to 1.28) | |
> 5 cups | 363/39 | 0.68 (0.48 to 0.97) | 0.70 (0.49 to 1.00) | |
P trend | 0.194 | 0.280 |