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Table 3 Results of multivariate analysis in Swedish study, overall and stratified by hormone receptor status

From: Coffee consumption modifies risk of estrogen-receptor negative breast cancer

Type of breast cancer Daily coffee consumption Controls/Cases ORa 95% CI ORbc 95% CI
All ≤ 1 cup 270/298 1.00 reference 1.00 reference
  > 1 to 3 cups 1,171/,277 1.00 0.83 1.20 1.01 0.84 1.23
  > 3 to 5 cups 846/904 0.96 0.79 1.16 1.00 0.82 1.22
  > 5 cups 363/328 0.80 0.64 0.99 0.84 0.66 1.06
  P trend   0.028 0.127
ER-positive ≤ 1 cup 270/161 1.00 reference 1.00 reference
  > 1 to 3 cups 1,171/685 0.99 0.80 1.23 1.03 0.82 1.30
  > 3 to 5 cups 846/501 0.99 0.79 1.23 1.07 0.84 1.36
  > 5 cups 363/169 0.77 0.59 1.00 0.87 0.65 1.15
  P trend   0.065 0.471
ER-negative ≤ 1 cup 270/48 1.00 reference 1.00 reference
  > 1 to 3 cups 1,171/148 0.74 0.52 1.05 0.77 0.53 1.11
  > 3 to 5 cups 846/92 0.58 0.40 0.85 0.60 0.40 0.89
  > 5 cups 363/31 0.44 0.27 0.71 0.43 0.25 0.72
  P trend   0.0002 0.0003
PR-positive ≤ 1 cup 270/135 1.00 reference 1.00 reference
  > 1 to 3 cups 1,171/603 1.04 0.83 1.31 1.05 0.83 1.34
  > 3 to 5 cups 846/434 1.01 0.80 1.29 1.09 0.85 1.40
  > 5 cups 363/144 0.77 0.58 1.02 0.84 0.62 1.13
  P trend   0.055 0.360
PR-negative ≤ 1 cup 270/66 1.00 reference 1.00 reference
  > 1 to 3 cups 1,171/212 0.75 0.55 1.02 0.85 0.61 1.17
  > 3 to 5 cups 846/150 0.71 0.52 0.98 0.75 0.53 1.05
  > 5 cups 363/55 0.59 0.40 0.88 0.67 0.44 1.01
  P trend   0.014 0.034
  1. aOdds ratio (OR) and corresponding 95% confidence intervals (CI) adjusted for matching factor (age at enrolment in years, continuous).
  2. bORs and corresponding 95% CI adjusted for age at enrolment, potential confounders (hormone replacement therapy (HRT), ever/never, ever smoked > 1 y or > 100 cigarettes, and education (elementary school, junior secondary school, high school or university)) and average daily alcohol consumption (g/day).
  3. Significant P values are in bold.
  4. ER, estrogen receptor; PR, progesterone receptor.