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Table 2 Correlation analysis of intrinsic subtypes with clinicopathological parameters, Treg and CXCL12 expression (n = 456)

From: Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers

  Luminal (n = 289) HER2 (n = 75) Basal-like (n = 62) Negative (n = 30) P-value
Patient age      
   Median (years) 56.0 55.2 54.0 52.7 0.64
Tumour size      
   Median 18.0 22.0 22.5 20.5 0.40
Tumour grade      < 0.001
1 71 (25%) 4 (5%) 2 (3%) 4 (13%)  
2 156 (55%) 16 (22%) 12 (20%) 12 (40%)  
3 58 (20%) 54 (73%) 47 (77%) 14 (47%)  
Nodal status      0.75
Negative 162 (56%) 40 (54%) 34 (55%) 17 (57%)  
Positive 125 (44%) 34 (46%) 28 (45%) 13 (43%)  
Treg      < 0.001
< 15 159 (62%) 28 (39%) 19 (25%) 23 (92%)  
≥15 99 (38%) 43 (61%) 36 (75%) 2 (8%)  
median 7.64 33.54 25.46 0.83  
CXCL12      0.050
Negative 36 (26%) 22 (47%) 11 (41%) 6 (35%)  
Positive 102 (74%) 25 (53%) 16 (59%) 11 (65%)  
  1. Treg, regulatory T cells.