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Table 3 PRLR single-nucleotide polymorphisms associated with breast cancer in the Polish Breast Cancer Study, by menopausal statusa

From: Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Single-nucleotide polymorphism Case Control OR (95% CI)b P Mean prolactin in sampled controlsc, ng/mL (95% CI) P trend
All subjects       
PRLR rs249537       
   CC 1,331 1,540 Referent    
   CT 388 400 1.12 (0.96-1.32) 0.15   
   TT 19 10 2.19 (1.02-4.73) 0.05   
   T vs. C    1.17 (1.01-1.35) 0.04   
PRLR rs13436213       
   GG 698 829 Referent    
   AG 814 885 1.09 (0.95-1.26) 0.21   
   AA 237 238 1.18 (0.96-1.46) 0.11   
   A vs. G    1.09 (0.99-1.20) 0.08   
PRLR rs7718468       
   TT 739 895 Referent    
   CT 771 831 1.12 (0.98-1.29) 0.10   
   CC 214 209 1.24 (1.00-1.54) 0.05   
   C vs. T    1.12 (1.01-1.23) 0.02   
Premenopausal       
PRLR rs249537       
   CC 351 492 Referent   5.50 (4.05-7.47)  
   CT 104 122 1.19 (0.88-1.59) 0.26 5.51 (3.86-7.87)  
   TT 12 2 8.42 (1.89-37.9) 0.01 3.83 (1.36-10.82)  
   T vs. C    1.39 (1.07-1.80) 0.01   0.84
PRLR rs13436213       
   GG 196 269 Referent   5.35 (3.90-7.33)  
   AG 220 265 1.14 (0.88-1.48) 0.32 5.30 (3.83-7.32)  
   AA 55 82 0.92 (0.62-1.36) 0.67 5.40 (3.75-7.80)  
   A vs. G    1.01 (0.85-1.20) 0.92   0.98
PRLR rs7718468       
   TT 204 286 Referent   5.79 (4.22-7.94)  
   CT 209 250 1.18 (0.91-1.53) 0.21 5.46 (3.90-7.64)  
   CC 50 72 0.97 (0.65-1.46) 0.90 5.21 (3.6-7.54)  
   C vs. T    1.05 (0.87-1.25) 0.63   0.31
Postmenopausal       
PRLR rs249537       
   CC 980 1,048 Referent   6.36 (5.01-8.07)  
   CT 284 278 1.11 (0.92-1.34) 0.28 6.45 (4.99-8.33)  
   TT 7 8 0.94 (0.34-2.61) 0.90 6.42 (3.64-11.32)  
   T vs. C    1.09 (0.92-1.31) 0.33   0.81
PRLR rs13436213       
   GG 502 560 Referent   6.29 (4.97-7.95)  
   AG 594 620 1.07 (0.91-1.27) 0.40 6.52 (5.15-8.25)  
   AA 182 156 1.32 (1.03-1.68) 0.03 6.48 (5.01-8.39)  
   A vs. G    1.13 (1.01-1.26) 0.04   0.48
PRLR rs7718468       
   TT 535 609 Referent   6.47 (5.09-8.22)  
   CT 562 581 1.11 (0.94-1.31) 0.21 6.86 (5.39-8.74)  
   CC 164 137 1.39 (1.07-1.79) 0.01 6.41 (4.89-8.4)  
   C vs. T    1.16 (1.03-1.30) 0.01   0.56
  1. aA complete list of single-nucleotide polymorphism associations with breast cancer risk can be found in Supplementary table S2 in Additional file 1. bOdds ratio (OR) and confidence interval (CI) adjusted for age and study site. cAdjusted for age, study site, time of blood collection, and time since last period (premenopausal only). PRLR, prolactin receptor (gene).