Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Table 3 PRLR single-nucleotide polymorphisms associated with breast cancer in the Polish Breast Cancer Study, by menopausal status^a

Single-nucleotide polymorphism	Case	Control	OR (95% CI)^b	P	Mean prolactin in sampled controls^c, ng/mL (95% CI)	P trend
All subjects
PRLR rs249537
CC	1,331	1,540	Referent
CT	388	400	1.12 (0.96-1.32)	0.15
TT	19	10	2.19 (1.02-4.73)	0.05
T vs. C			1.17 (1.01-1.35)	0.04
PRLR rs13436213
GG	698	829	Referent
AG	814	885	1.09 (0.95-1.26)	0.21
AA	237	238	1.18 (0.96-1.46)	0.11
A vs. G			1.09 (0.99-1.20)	0.08
PRLR rs7718468
TT	739	895	Referent
CT	771	831	1.12 (0.98-1.29)	0.10
CC	214	209	1.24 (1.00-1.54)	0.05
C vs. T			1.12 (1.01-1.23)	0.02
Premenopausal
PRLR rs249537
CC	351	492	Referent		5.50 (4.05-7.47)
CT	104	122	1.19 (0.88-1.59)	0.26	5.51 (3.86-7.87)
TT	12	2	8.42 (1.89-37.9)	0.01	3.83 (1.36-10.82)
T vs. C			1.39 (1.07-1.80)	0.01		0.84
PRLR rs13436213
GG	196	269	Referent		5.35 (3.90-7.33)
AG	220	265	1.14 (0.88-1.48)	0.32	5.30 (3.83-7.32)
AA	55	82	0.92 (0.62-1.36)	0.67	5.40 (3.75-7.80)
A vs. G			1.01 (0.85-1.20)	0.92		0.98
PRLR rs7718468
TT	204	286	Referent		5.79 (4.22-7.94)
CT	209	250	1.18 (0.91-1.53)	0.21	5.46 (3.90-7.64)
CC	50	72	0.97 (0.65-1.46)	0.90	5.21 (3.6-7.54)
C vs. T			1.05 (0.87-1.25)	0.63		0.31
Postmenopausal
PRLR rs249537
CC	980	1,048	Referent		6.36 (5.01-8.07)
CT	284	278	1.11 (0.92-1.34)	0.28	6.45 (4.99-8.33)
TT	7	8	0.94 (0.34-2.61)	0.90	6.42 (3.64-11.32)
T vs. C			1.09 (0.92-1.31)	0.33		0.81
PRLR rs13436213
GG	502	560	Referent		6.29 (4.97-7.95)
AG	594	620	1.07 (0.91-1.27)	0.40	6.52 (5.15-8.25)
AA	182	156	1.32 (1.03-1.68)	0.03	6.48 (5.01-8.39)
A vs. G			1.13 (1.01-1.26)	0.04		0.48
PRLR rs7718468
TT	535	609	Referent		6.47 (5.09-8.22)
CT	562	581	1.11 (0.94-1.31)	0.21	6.86 (5.39-8.74)
CC	164	137	1.39 (1.07-1.79)	0.01	6.41 (4.89-8.4)
C vs. T			1.16 (1.03-1.30)	0.01		0.56

^aA complete list of single-nucleotide polymorphism associations with breast cancer risk can be found in Supplementary table S2 in Additional file 1. ^bOdds ratio (OR) and confidence interval (CI) adjusted for age and study site. ^cAdjusted for age, study site, time of blood collection, and time since last period (premenopausal only). PRLR, prolactin receptor (gene).

ISSN: 1465-542X