Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland

Table 2 PRL and PRLR single-nucleotide polymorphisms genotyped in the Polish Breast Cancer Study

Single-nucleotide polymorphism	Chromosome	Base pair coordinate^a	Location	Alleles	MAF^b	P _HWE ^c
PRLR
rs37364	5	35108137	Intron 7	A/C	0.21	0.58
rs43215	5	35122726	Intron 3	G/A	0.12	0.67
rs249537	5	35125057	Intron 3	C/T	0.11	3.0 × 10^-3
rs7734558	5	35150368	Intron 3	C/T	0.48	0.03
rs62355518	5	35218778	Intron 3	A/G	0.16	0.68
rs10941235	5	35221337	Intron 3	G/A	0.27	0.49
rs13436213	5	35221583	Intron 3	G/A	0.35	1
rs4425481	5	35221654	Intron 3	G/T	0.06	0.20
rs1610218	5	35222451	Intron 3	G/A	0.04	0.63
rs17249539	5	35233127	Intron 3	C/G	0.12	0.79
rs12153280	5	35235019	Intron 3	G/T	0.11	<1.0 × 10^-4
rs873456	5	35235414	Intron 3	G/T	0.34	0.90
rs7718468	5	35236793	Intron 3	T/C	0.32	0.53
rs34024951	5	35246079	Intron 3	G/A	0.10	0.95
rs9292575	5	35250262	Intron 3	C/A	0.09	0.74
rs10038062	5	35256276	Intron 3	A/G	0.09	0.76
rs7731880	5	35257203	Intron 3	G/C	0.12	<1.0 × 10^-4
rs931741	5	35257808	Intron 3	C/G	0.31	0.83
rs7735260	5	35262772	Intron 3	C/T	0.16	4.9 × 10^-3
rs10068521	5	35266137	Exon 1	C/G	0.03	0.42
PRL
rs849872	6	22391011	3' UTR	A/G	0.15	0.60
rs849870	6	22391864	3' UTR	G/A	0.14	0.56
rs1205960	6	22396139	3' UTR	G/A	0.25	0.13
rs849886	6	22399346	Intron 3	G/A	0.46	0.94
rs2244502	6	22402966	Intron 3	A/T	0.31	0.23
rs12202764	6	22403312	Intron 3	A/T	0.27	0.16
rs3756824	6	22406716	5'	G/C	0.03	0.07
rs9466314	6	22414284	5'	T/T	0	1

^aSingle-Nucleotide Polymorphism database (dbSNP) build 36.3. ^bMinor allele frequency in controls only. ^cTest of Hardy-Weinberg equilibrium in controls only. PRL, prolactin (gene); PRLR, prolactin receptor (gene); UTR, untranslated region.

ISSN: 1465-542X