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Table 1 Association between variants at the MORF4L1 locus and breast cancer risk

From: Exploring the link between MORF4L1 and risk of breast cancer

Variant Genotype BRCA1mutation carriers BRCA2mutation carriers CGEMS
   n HR 95% CI n HR 95% CI n OR 95% CI
rs7164529 GG 2,437 1.00 - 1,587 1.00 - 833 1.00 -
  GA 2,998 1.04 0.97 to 1.13 1,813 1.07 0.98 to 1.17 1,087 1.23 1.02 to 1.47
  AA 928 1.02 0.92 to 1.14 568 1.12 0.99 to 1.27 366 0.83 0.65 to 1.06
  Trend   1.02 0.97 to 1.07   1.06 1.00 to 1.12   0.97 0.86 to 1.09
  P trend    0.45    0.05    0.58
  P 2df    0.51    0.14    0.003
rs10519219 TT 4,366 1.00 - 2,760 1.00 - 1,766 1.00 -
  TC 1,331 0.99 0.91 to 1.08 866 0.96 0.86 to 1.06 500 0.78 0.64 to 0.96
  CC 95 1.10 0.84 to 1.43 78 1.39 1.02 to 1.88 21 0.38 0.14 to 0.97
  Trend   1.00 0.93 to 1.08   1.02 0.93 to 1.11   0.76 0.63 to 0.91
  P trend    0.92    0.72    0.003
  P 2df    0.76    0.07    0.008
  P recessive    0.49    0.033    0.045
  1. Association study between variants at the MORF4L1 locus and breast cancer risk among BRCA1 and BRCA2 mutation carriers, and in the general population (CGEMS results). n, number of individuals; HR, hazard ratio; CI, confidence interval; OR, odds ratio.