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Table 1 Association between variants at the MORF4L1 locus and breast cancer risk

From: Exploring the link between MORF4L1 and risk of breast cancer

Variant

Genotype

BRCA1mutation carriers

BRCA2mutation carriers

CGEMS

  

n

HR

95% CI

n

HR

95% CI

n

OR

95% CI

rs7164529

GG

2,437

1.00

-

1,587

1.00

-

833

1.00

-

 

GA

2,998

1.04

0.97 to 1.13

1,813

1.07

0.98 to 1.17

1,087

1.23

1.02 to 1.47

 

AA

928

1.02

0.92 to 1.14

568

1.12

0.99 to 1.27

366

0.83

0.65 to 1.06

 

Trend

 

1.02

0.97 to 1.07

 

1.06

1.00 to 1.12

 

0.97

0.86 to 1.09

 

P trend

  

0.45

  

0.05

  

0.58

 

P 2df

  

0.51

  

0.14

  

0.003

rs10519219

TT

4,366

1.00

-

2,760

1.00

-

1,766

1.00

-

 

TC

1,331

0.99

0.91 to 1.08

866

0.96

0.86 to 1.06

500

0.78

0.64 to 0.96

 

CC

95

1.10

0.84 to 1.43

78

1.39

1.02 to 1.88

21

0.38

0.14 to 0.97

 

Trend

 

1.00

0.93 to 1.08

 

1.02

0.93 to 1.11

 

0.76

0.63 to 0.91

 

P trend

  

0.92

  

0.72

  

0.003

 

P 2df

  

0.76

  

0.07

  

0.008

 

P recessive

  

0.49

  

0.033

  

0.045

  1. Association study between variants at the MORF4L1 locus and breast cancer risk among BRCA1 and BRCA2 mutation carriers, and in the general population (CGEMS results). n, number of individuals; HR, hazard ratio; CI, confidence interval; OR, odds ratio.
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Breast Cancer Research

ISSN: 1465-542X

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