| All subjects | Premenopausal | Postmenopausal |  | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locus | WW ca/co | WV ca/co | VV ca/co | OR (95% CI) | P | PACTb | WW ca/co | WV ca/co | VV ca/co | OR (95% CI) | P | PACTb | WW ca/co | WV ca/co | VV ca/co | OR (95% CI) | P | PACTb | P int†|
SLCO1B1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs11045773 | 898/857 | 401/468 | 50/67 | 0.83 (0.72-0.94) | 0.0047 | 0.088 | 227/206 | 118/127 | 18/13 | 0.94 (0.72-1.21) | 0.61 | 1.00 | 659/636 | 273/332 | 29/54 | 0.77 (0.65-0.90) | 0.0009 | 0.020 | 0.17 |
rs11045777 | 899/855 | 401/471 | 50/64 | 0.83 (0.73-0.95) | 0.0053 | 0.099 | 227/204 | 118/129 | 18/11 | 0.94 (0.73-1.22) | 0.66 | 1.00 | 660/636 | 273/333 | 29/53 | 0.77 (0.65-0.90) | 0.0009 | 0.019 | 0.17 |
rs976754 | 1,126/1,207 | 217/183 | 8/5 | 1.27 (1.03-1.55) | 0.018 | 0.26 | 309/294 | 50/51 | 5/2 | 1.04 (0.71-1.53) | 0.76 | 1.00 | 795/894 | 164/127 | 3/3 | 1.40 (1.10-1.79) | 0.0046 | 0.077 | 0.15 |
rs16923519 | 836/921 | 452/421 | 62/53 | 1.17 (1.02-1.33) | 0.018 | 0.26 | 244/222 | 107/114 | 12/11 | 0.92 (0.70-1.20) | 0.53 | 1.00 | 577/685 | 335/297 | 50/42 | 1.26 (1.08-1.47) | 0.0019 | 0.038 | 0.029 |
rs4149057 | 496/569 | 641/638 | 209/186 | 1.14 (1.02-1.27) | 0.021 | 0.28 | 152/133 | 164/172 | 48/42 | 0.96 (0.77-1.19) | 0.70 | 1.00 | 334/429 | 466/453 | 157/140 | 1.22 (1.07-1.39) | 0.0024 | 0.046 | 0.047 |
rs4149058 | 778/854 | 468/467 | 95/72 | 1.15 (1.02-1.30) | 0.029 | 0.34 | 220/204 | 122/120 | 21/22 | 0.94 (0.73-1.20) | 0.66 | 1.00 | 541/636 | 342/337 | 71/50 | 1.23 (1.07-1.43) | 0.0043 | 0.074 | 0.052 |
rs11045884 | 880/871 | 412/452 | 41/63 | 0.86 (0.75-0.99) | 0.031 | 0.36 | 216/220 | 126/107 | 15/16 | 1.09 (0.84-1.42) | 0.42 | 1.00 | 649/638 | 277/335 | 25/46 | 0.78 (0.66-0.92) | 0.0023 | 0.044 | 0.033 |
rs11045825 | 953/943 | 357/394 | 38/55 | 0.87 (0.75-1.00) | 0.045 | 0.45 | 237/236 | 112/97 | 14/13 | 1.09 (0.83-1.42) | 0.54 | 1.00 | 700/692 | 237/288 | 23/42 | 0.79 (0.66-0.93) | 0.0040 | 0.068 | 0.037 |
rs10841767 | 889/874 | 411/451 | 49/67 | 0.88 (0.77-1.00) | 0.049 | 0.47 | 221/222 | 125/107 | 17/18 | 1.07 (0.83-1.38) | 0.51 | 1.00 | 653/639 | 277/334 | 31/48 | 0.80 (0.69-0.94) | 0.0059 | 0.091 | 0.058 |
rs11045813 | 917/918 | 372/401 | 37/56 | 0.88 (0.76-1.01) | 0.068 | 0.58 | 225/229 | 118/99 | 13/12 | 1.12 (0.85-1.47) | 0.40 | 1.00 | 677/676 | 245/293 | 23/44 | 0.79 (0.67-0.94) | 0.0051 | 0.082 | 0.024 |
HSD17B4 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs382719 | 393/457 | 672/685 | 275/241 | 1.16 (1.04-1.29) | 0.0084 | 0.097 | 105/124 | 179/172 | 76/51 | 1.32 (1.06-1.64) | 0.012 | 0.12 | 282/329 | 479/499 | 194/184 | 1.11 (0.98-1.26) | 0.11 | 0.657 | 0.16 |
rs17388769 | 919/1,002 | 393/364 | 33/21 | 1.21 (1.04-1.41) | 0.012 | 0.13 | 243/258 | 108/89 | 11/0 | 1.56 (1.15-2.13) | 0.004 | 0.051 | 656/729 | 280/266 | 22/21 | 1.12 (0.94-1.34) | 0.15 | 0.77 | 0.074 |