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Table 1 Selected ontologies of commonly upregulated genes

From: The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines

Term Genesa Gene set on the array Z-score
Biological process    
   Response to stimulus 39 3,137 4.82
   Response to stress 27 1,753 5.05
   Response to unfolded proteinb 3 62 4.14
   Acute inflammatory responseb 5 99 5.5
   Acute-phase responseb 4 43 7.11
   Regulation of acute inflammatory responseb 3 26 6.95
   Response to chemical stimulus 21 1,396 4.26
   Response to organic substanceb 15 845 4.25
   Response to hormone stimulusb 10 440 4.35
   Response to steroid hormone stimulusb 7 220 4.75
   Response to glucocorticoid stimulusb 6 94 6.98
   Leukocyte chemotaxisb 3 60 4.23
   Response to oxygen levelsb 5 151 4.12
   Response to toxinb 3 64 4.05
   Response to extracellular stimulus 7 242 4.41
   Positive regulation of response to external stimulusb 4 87 4.63
   Cellular response to extracellular stimulusb 5 82 6.19
   Cellular response to nutrient levelsb 4 62 5.73
   Cellular response to starvationb 3 43 5.2
   Response to biotic stimulus 10 424 4.49
   Response to virusb 6 147 5.24
   Cell death 24 1,227 6.04
   Apoptosis 22 1,116 5.8
   Regulation of cell deathb 17 872 4.99
   Regulation of apoptosisb 16 859 4.62
   Negative regulation of cell deathb 10 402 4.69
   Negative regulation of apoptosisb 9 391 4.16
   Induction of apoptosisb 8 333 4.06
   Anti-apoptosisb 8 226 5.49
   Positive regulation of anti-apoptosisb 3 32 6.18
   Cellular component disassembly involved in apoptosisb 3 27 6.81
   Release of cytochrome c from mitochondriab 3 24 7.27
   Protein folding 6 158 4.99
   Leukocyte migration 4 86 4.66
   Autophagy 3 48 4.86
   Regulation of synaptic plasticity 3 57 4.37
   Iron ion homeostasis 4 31 8.54
   Positive regulation of smooth muscle cell proliferation 3 28 6.67
   Regulation of viral reproduction 3 28 6.67
Cellular component    
   Integral to membrane 9 4,459 -4.27
   Autophagic vacuole 3 20 8.2
Molecular functions    
   Heat-shock protein binding 5 71 7.14
   Unfolded protein binding 5 103 5.69
   Antioxidant activity 3 45 5.35
  1. aNumber of genes differentially expressed within the assigned ontology. bSubcategory within a given ontology.