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Figure 4 | Breast Cancer Research

Figure 4

From: The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines

Figure 4

Morphological features of autophagy in CTet-treated MDA-MB-231 cells. Autophagy induction in MDA-MB-231 cells following exposure to CTet was detected by recruitment of LC3b protein to autophagosomes (a) and fusion between autophagosomes and lysosomes in terms of co-localization of LC3b and the lysosome marker LAMP2a (b). CTet, indole-3-carbinol cyclic tetrameric derivative; CTR, control; LAMP2a, lysosome-associated membrane protein type 2a; LC3b, microtubule-associated protein 1 light chain 3.

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