Vitamin D and breast cancer: interpreting current evidence

Breast Cancer Research

Table 1 25-Hydroxyvitamin D and breast cancer incidence: nested case-control studies in cohorts

Cohort	Lead author	Cohort (n)	Case patients (n)	Control subjects (n)	P _trend ^a
Cancer Prevention Study II Nutrition Cohort	McCullough	21,965	516	516	0.60
Malmo Diet and Cancer Study	Almquist	53,000	764	764	NS
Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial	Freedman	38,660	1,005	1,005	0.81
Women's Health Initiative	Chlebowski	32,826	895	898	0.20
Nurses' Health Study	Bertone-Johnson	32,826	701	724	0.06
French E3N Cohort	Engel	17,391	636	1,272	0.02^b

^aP_trend for analyses comparing breast cancer incidence in low versus high 25-hydroxyvitamin D groups. ^bFindings driven by results in women <53 years old at sampling.

ISSN: 1465-542X