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Table 1 Biological pathways regulated by estrogen plus 40 nM endoxifen relative to estrogen treatment alone

From: Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen

  MCF7 Parental Cells   
Pathway # Pathway Name P-Value # Genes
1* Immune response_Antiviral actions of Interferons 0.0008 6/20
2* Immune response_IFN gamma signaling pathway 0.0177 6/36
3 Regulation of lipid metabolism_Regulation of fatty acid synthase activity 0.0182 3/10
4 Neurodisease_Parkin disorder under Parkinson disease 0.0191 4/18
5* Regulation of lipid metabolism_Regulation of acetyl-CoA carboxylase 1 0.0195 2/4
6* Cholesterol Biosynthesis 0.0276 4/20
7* Niacin-HDL metabolism 0.0305 3/12
8* Cytoskeleton remodeling_Thyroliberin in cytoskeleton remodeling 0.0305 3/12
9 CFTR-dependent regulation of ion channels in Airway Epithelium 0.0326 4/21
10 Immune response_IL-27 signaling pathway 0.0380 3/13
11* Development_A1 receptor signaling 0.0440 4/23
12* Neurophysiological process_PGE2-induced pain processing 0.0450 2/6
13* Immune response_Th1 and Th2 cell differentiation 0.0463 3/14
  MCF7-ERβ Cells   
1* wtCFTR and deltaF508 traffic/Membrane expression (norm and CF) 0.0026 5/16
2 Regulation of lipid metabolism_Regulation of fatty acid synthase activity 0.0026 4/10
3 Immune response_IL-27 signaling pathway 0.0077 4/13
4* Blood coagulation_Blood coagulation 0.0132 4/15
5* Cell cycle_ERα regulation of G1/S transition 0.0167 5/24
6* Globo-(isoglobo) series GSL Metabolism 0.0228 3/10
7 Neurodisease_Parkin disorder under Parkinson disease 0.0254 4/18
8* ERα action on cytoskeleton remodeling and cell migration 0.0299 3/11
9* Transcription_Ligand-Dependent Transcription of Retinoid-Target genes 0.0306 4/19
10* ENaC regulation in airways (normal and CF) 0.0364 4/20
11 CFTR-dependent regulation of ion channels in Airway Epithelium 0.0427 4/21
12* wtCFTR and delta508-CFTR traffic/Generic schema (norm and CF) 0.0463 5/31