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Figure 6 | Breast Cancer Research

Figure 6

From: Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen

Figure 6

Microarray analysis of estrogen and estrogen plus endoxifen treatment in parental and MCF7-ERβ cells. (A and C) Venn diagrams indicating the number of genes whose expression levels were significantly altered by at least 1.5-fold in response to 24-hour treatments of 1 nM estrogen in MCF7 or MCF7-ERβ cells (A) or 1 nM estrogen + 40 nM endoxifen relative to estrogen treatment alone (C). (B and D) Real-time PCR confirmation of selected genes whose expression levels were either increased or decreased by the addition of estrogen in MCF7 or MCF7-ERβ cells (B) or 1 nM estrogen + 40 nM endoxifen relative to estrogen treatment alone (D). The fold changes of each gene as detected by microarray analysis are shown for comparison purposes and all data have been normalized to vehicle controls (dotted line).

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