Figure 5From: Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expressionHypothetic pathways by which Pokemon regulates survivin expression. p53 suppresses survivin expression and induces cell apoptosis or senescence [28, 29]. Pokemon activates survivin signaling by suppressing the ARF/p53 pathway [1]. The present study shows that Pokemon also enhances survivin expression via direct binding to its promoter, promoting breast oncogenesis.Back to article page