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Table 3 Expression correlation of microRNA and inversely expressed predicted targetsa

From: Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer

microRNA expression

Gene expression

miRNA:mRNA

miRNA

Fold change

Probe ID

Gene symbols, gene names

Fold change

Expression correlation

P valueb

let-7c

0.03

203481_at

C10ORF6, chromosome 10 open reading frame 6

1.58

-0.58

1.88E-02

  

218567_x_at

DPP3, dipeptidylpeptidase 3

2.31

-0.49

5.4E-02

  

203358_s_at

EZH2, enhancer of zeste homolog 2 (Drosophila)

2.36

-0.64

7.69E-03

  

209283_at

SLC20A1, solute carrier family 20 (phosphate transporter), member 1

2.06

-0.30

2.53E-01

  

203358_s_at

TRIB1, tribbles homolog 1 (Drosophila)

1.77

-0.48

5.84E-02

miR-10b

0.04

202357_s_at

SDC1, syndecan 1

2.06

-0.28

2.96E-01

miR-125b

0.05

203744_at

HMGB3, high-mobility group box 3

2.13

-0.61

1.27E-02

  

209613_s_at

NRIP1, nuclear receptor interacting protein 1

2.25

-0.39

1.36E-01

  

213004_at

MEMO1, mediator of cell motility 1

1.73

-0.59

1.54E-02

miR-17-3p

0.12

203744_at

HMGB3, high-mobility group box 3

2.13

-0.49

5.66E-02

  

212446_s_at

LASS6, LAG1 longevity assurance homolog 6

1.78

-0.31

2.38E-01

  

211653_x_at

MAP7, microtubule-associated protein 7

1.73

-0.49

5.19E-02

  

213492_at

SERP1, stress-associated endoplasmic reticulum protein 1

1.80

-0.23

3.84E-01

  

203213_at

SAR1B, SAR1 gene homolog B (Saccharomyces cerevisiae)

1.95

-0.07

8.03E-01

  

202381_at

ADAM9, ADAM metallopeptidase domain 9

2.04

-0.45

7.89E-02

miR-181b

5.46

221234_s_at

BACH2, BTB and CNC homology 1 basic leucine zipper transcription factor 2

0.47

-0.30

2.62E-01

  

212914_at

CBX7, chromobox homolog 7

0.44

-0.30

2.67E-01

  

204753_s_at

204755_x_at

204754_at

HLF, hepatic leukemia factor

0.24

0.28

0.31

-0.19

-0.52

-0.45

4.84E-01

3.82E-02

7.70E-02

  

204567_s_at

NMT2, N-myristoyltransferase 2

0.58

-0.35

1.81E-01

  

202274_at

200974_at

NR3C1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

0.46

0.57

-0.44

-0.57

8.86E-02

2.21E-02

miR-182

72.35

221234_s_at

BACH2, BTB and CNC homology 1 basic leucine zipper transcription factor 2

0.47

-0.73

1.41E-03

  

210347_s_at

219497_s_at

219498_s_at

BCL11A, B-cell CLL/lymphoma 11A

0.27

0.42

0.43

-0.65

-0.69

-0.80

6.31E-03

2.86E-03

2.19E-04

  

221530_s_at

BHLHB3, basic helix-loop-helix domain containing, class B, 3

0.47

-0.55

2.71E-02

  

204851_s_at

204850_s_at

DCX, doublecortex; lissencephaly, X-linked (doublecortin)

0.13

0.30

-0.83

-0.67

7.48E-05

4.63E-03

  

209691_s_at

DOK4, docking protein 4

0.56

-0.53

3.65E-02

  

209905_at

214651_s_at

HOXA9, homeobox A9

0.10

0.31

-0.64

-0.55

8.18E-03

2.63E-02

  

64900_at

LPHN2, latrophilin 2

0.37

-0.62

9.87E-03

  

219497_s_at

PRKD1, protein kinase D1

0.54

-0.59

1.61E-02

  

210735_s_at

RIMS3, regulating synaptic membrane exocytosis 3

0.52

-0.73

1.25E-03

  

205022_s_at

FOXN3, checkpoint repressor 1

0.50

-0.67

4.40E-03

  

221935_s_at

NCAM1, neural cell adhesion molecule 1

0.43

-0.41

1.19E-01

  

212914_at

CBX7, chromobox homolog 7

0.44

-0.57

2.22E-02

  

204567_s_at

NMT2, N-myristoyltransferase 2

0.58

-0.26

3.26E-01

miR-183

51.88

221234_s_at

BACH2, BTB and CNC homology 1 basic leucine zipper transcription factor 2

0.47

-0.75

7.83E-04

  

204851_s_at

204850_s_at

DCX, doublecortex; lissencephaly, X-linked (doublecortin)

0.13

0.30

-0.82

-0.80

1.06E-04

2.16E-04

  

201693_s_at

EGR1, early growth response 1

0.45

-0.61

1.12E-02

  

202274_at

200974_at

NR3C1, nuclear receptor subfamily 3, group C, member 1

(glucocorticoid receptor)

0.46

0.57

-0.70

-0.45

2.77E-03

8.08E-02

miR-195

0.13

217852_s_at

ARL8B, ADP ribosylation factor-like 8B

1.64

-0.31

2.49E-01

  

208712_at

CCND1, cyclin D1[43]

2.30

-0.33

2.19E-01

  

208653_s_at

CD164, CD164 molecule, sialomucin

2.40

-0.54

3.16E-02

  

202596_at

ENSA, endosulfine α

2.03

-0.37

1.54E-01

  

211653_x_at

MAP7, microtubule-associated protein 7

1.73

-0.52

4.00E-02

  

221935_s_at

RAD23B, RAD23 homolog B

1.79

-0.08

7.61E-01

  

201341_at

TMEM33, transmembrane protein 33

1.62

-0.30

2.64E-01

  

212464_s_at

216442_x_at

WWP1, WW domain containing E3 ubiquitin protein ligase 1

2.79

2.83

-0.49

-0.25

5.57E-02

5.57E-02

miR-204

0.08

217852_s_at

ARL8B, ADP-ribosylation factor-like 8B

1.64

-0.27

3.06E-01

  

213492_at

SERP1, stress-associated endoplasmic reticulum protein 1

1.80

-0.57

2.22E-02

miR-21

20.92

218992_at

219060_at

NFIB, nuclear factor I/B[42]

0.43

0.52

-0.75

-0.69

9.15E-04

3.28E-03

miR-7

5.19

213492_at

COL2A1, collagen type II, α1

0.51

-0.12

6.61E-01

  

204359_at

FLRT2, fibronectin leucine-rich transmembrane protein 2

0.35

-0.49

5.36E-02

  

206765_at

KCNJ2, potassium inwardly rectifying channel, subfamily J, member 2

0.33

-0.73

1.35E-03

  

214112_s_at

SNCA, synuclein α

0.48

-0.54

3.00E-02

  

205022_s_at

FOXN3, checkpoint repressor 1

0.50

-0.61

1.22E-02

miR-93

160.47

210347_s_at

219497_s_at

219498_s_at

BCL11A, B-cell CLL/lymphoma 11A

0.27

0.42

0.43

-0.75

-0.72

-0.71

7.40E-04

1.51E-03

2.11E-03

  

204753_s_at

204755_x_at

204754_at

HLF, hepatic leukemia factor

0.24

0.28

0.31

-0.68

-0.81

-0.81

3.60E-03

1.44E-04

1.49E-04

  

218992_at

219060_at

NFIB, nuclear factor I/B

0.43

0.52

-0.74

-0.65

1.14E-03

6.30E-03

  

203963_at

RGL1, ral guanine nucleotide dissociation stimulator-like 1

0.53

-0.58

1.79E-02

  

204422_s_at

205117_at

TXNIP, thioredoxin-interacting protein

0.36

0.49

-0.69

-0.57

2.96E-03

2.14E-02

  1. amiRNA, microRNA; miRNA:target mRNA pairs tested in this study are indicated by boldface type, and previously confirmed targets from the literature are indicated by boldface italicized type, bP value determined by Student's t-test.