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Table 3 Expression correlation of microRNA and inversely expressed predicted targetsa

From: Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer

microRNA expression Gene expression miRNA:mRNA
miRNA Fold change Probe ID Gene symbols, gene names Fold change Expression correlation P valueb
let-7c 0.03 203481_at C10ORF6, chromosome 10 open reading frame 6 1.58 -0.58 1.88E-02
   218567_x_at DPP3, dipeptidylpeptidase 3 2.31 -0.49 5.4E-02
   203358_s_at EZH2, enhancer of zeste homolog 2 (Drosophila) 2.36 -0.64 7.69E-03
   209283_at SLC20A1, solute carrier family 20 (phosphate transporter), member 1 2.06 -0.30 2.53E-01
   203358_s_at TRIB1, tribbles homolog 1 (Drosophila) 1.77 -0.48 5.84E-02
miR-10b 0.04 202357_s_at SDC1, syndecan 1 2.06 -0.28 2.96E-01
miR-125b 0.05 203744_at HMGB3, high-mobility group box 3 2.13 -0.61 1.27E-02
   209613_s_at NRIP1, nuclear receptor interacting protein 1 2.25 -0.39 1.36E-01
   213004_at MEMO1, mediator of cell motility 1 1.73 -0.59 1.54E-02
miR-17-3p 0.12 203744_at HMGB3, high-mobility group box 3 2.13 -0.49 5.66E-02
   212446_s_at LASS6, LAG1 longevity assurance homolog 6 1.78 -0.31 2.38E-01
   211653_x_at MAP7, microtubule-associated protein 7 1.73 -0.49 5.19E-02
   213492_at SERP1, stress-associated endoplasmic reticulum protein 1 1.80 -0.23 3.84E-01
   203213_at SAR1B, SAR1 gene homolog B (Saccharomyces cerevisiae) 1.95 -0.07 8.03E-01
   202381_at ADAM9, ADAM metallopeptidase domain 9 2.04 -0.45 7.89E-02
miR-181b 5.46 221234_s_at BACH2, BTB and CNC homology 1 basic leucine zipper transcription factor 2 0.47 -0.30 2.62E-01
   212914_at CBX7, chromobox homolog 7 0.44 -0.30 2.67E-01
   204753_s_at
204755_x_at
204754_at
HLF, hepatic leukemia factor 0.24
0.28
0.31
-0.19
-0.52
-0.45
4.84E-01
3.82E-02
7.70E-02
   204567_s_at NMT2, N-myristoyltransferase 2 0.58 -0.35 1.81E-01
   202274_at
200974_at
NR3C1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.46
0.57
-0.44
-0.57
8.86E-02
2.21E-02
miR-182 72.35 221234_s_at BACH2, BTB and CNC homology 1 basic leucine zipper transcription factor 2 0.47 -0.73 1.41E-03
   210347_s_at
219497_s_at
219498_s_at
BCL11A, B-cell CLL/lymphoma 11A 0.27
0.42
0.43
-0.65
-0.69
-0.80
6.31E-03
2.86E-03
2.19E-04
   221530_s_at BHLHB3, basic helix-loop-helix domain containing, class B, 3 0.47 -0.55 2.71E-02
   204851_s_at
204850_s_at
DCX, doublecortex; lissencephaly, X-linked (doublecortin) 0.13
0.30
-0.83
-0.67
7.48E-05
4.63E-03
   209691_s_at DOK4, docking protein 4 0.56 -0.53 3.65E-02
   209905_at
214651_s_at
HOXA9, homeobox A9 0.10
0.31
-0.64
-0.55
8.18E-03
2.63E-02
   64900_at LPHN2, latrophilin 2 0.37 -0.62 9.87E-03
   219497_s_at PRKD1, protein kinase D1 0.54 -0.59 1.61E-02
   210735_s_at RIMS3, regulating synaptic membrane exocytosis 3 0.52 -0.73 1.25E-03
   205022_s_at FOXN3, checkpoint repressor 1 0.50 -0.67 4.40E-03
   221935_s_at NCAM1, neural cell adhesion molecule 1 0.43 -0.41 1.19E-01
   212914_at CBX7, chromobox homolog 7 0.44 -0.57 2.22E-02
   204567_s_at NMT2, N-myristoyltransferase 2 0.58 -0.26 3.26E-01
miR-183 51.88 221234_s_at BACH2, BTB and CNC homology 1 basic leucine zipper transcription factor 2 0.47 -0.75 7.83E-04
   204851_s_at
204850_s_at
DCX, doublecortex; lissencephaly, X-linked (doublecortin) 0.13
0.30
-0.82
-0.80
1.06E-04
2.16E-04
   201693_s_at EGR1, early growth response 1 0.45 -0.61 1.12E-02
   202274_at
200974_at
NR3C1, nuclear receptor subfamily 3, group C, member 1
(glucocorticoid receptor)
0.46
0.57
-0.70
-0.45
2.77E-03
8.08E-02
miR-195 0.13 217852_s_at ARL8B, ADP ribosylation factor-like 8B 1.64 -0.31 2.49E-01
   208712_at CCND1, cyclin D1[43] 2.30 -0.33 2.19E-01
   208653_s_at CD164, CD164 molecule, sialomucin 2.40 -0.54 3.16E-02
   202596_at ENSA, endosulfine α 2.03 -0.37 1.54E-01
   211653_x_at MAP7, microtubule-associated protein 7 1.73 -0.52 4.00E-02
   221935_s_at RAD23B, RAD23 homolog B 1.79 -0.08 7.61E-01
   201341_at TMEM33, transmembrane protein 33 1.62 -0.30 2.64E-01
   212464_s_at
216442_x_at
WWP1, WW domain containing E3 ubiquitin protein ligase 1 2.79
2.83
-0.49
-0.25
5.57E-02
5.57E-02
miR-204 0.08 217852_s_at ARL8B, ADP-ribosylation factor-like 8B 1.64 -0.27 3.06E-01
   213492_at SERP1, stress-associated endoplasmic reticulum protein 1 1.80 -0.57 2.22E-02
miR-21 20.92 218992_at
219060_at
NFIB, nuclear factor I/B[42] 0.43
0.52
-0.75
-0.69
9.15E-04
3.28E-03
miR-7 5.19 213492_at COL2A1, collagen type II, α1 0.51 -0.12 6.61E-01
   204359_at FLRT2, fibronectin leucine-rich transmembrane protein 2 0.35 -0.49 5.36E-02
   206765_at KCNJ2, potassium inwardly rectifying channel, subfamily J, member 2 0.33 -0.73 1.35E-03
   214112_s_at SNCA, synuclein α 0.48 -0.54 3.00E-02
   205022_s_at FOXN3, checkpoint repressor 1 0.50 -0.61 1.22E-02
miR-93 160.47 210347_s_at
219497_s_at
219498_s_at
BCL11A, B-cell CLL/lymphoma 11A 0.27
0.42
0.43
-0.75
-0.72
-0.71
7.40E-04
1.51E-03
2.11E-03
   204753_s_at
204755_x_at
204754_at
HLF, hepatic leukemia factor 0.24
0.28
0.31
-0.68
-0.81
-0.81
3.60E-03
1.44E-04
1.49E-04
   218992_at
219060_at
NFIB, nuclear factor I/B 0.43
0.52
-0.74
-0.65
1.14E-03
6.30E-03
   203963_at RGL1, ral guanine nucleotide dissociation stimulator-like 1 0.53 -0.58 1.79E-02
   204422_s_at
205117_at
TXNIP, thioredoxin-interacting protein 0.36
0.49
-0.69
-0.57
2.96E-03
2.14E-02
  1. amiRNA, microRNA; miRNA:target mRNA pairs tested in this study are indicated by boldface type, and previously confirmed targets from the literature are indicated by boldface italicized type, bP value determined by Student's t-test.