Figure 2

Effect of miR-125b overexpression and miR-182 and miR-183 knockdown on predicted target gene expression. (A) Reduced average relative fold change in expression of predicted miR-125b targets: mediator of ErbB2-driven cell motility 1 (MEMO1) (*P < 0.08) and nuclear receptor interacting protein 1 (NRIP1(RIP140)) (*P < 0.05). (B) Increased average relative fold change in expression of predicted miR-182 targets: chromobox homolog 7 (CBX7), docking protein 4 (DOK4) and N-myristoyltransferase 2 (NMT2) and miR-183 target early growth response 1 (EGR1) (*P < 0.05 and **P < 0.02). Target mRNA expression was measured at 24, 48 and 72 hours posttransfection (n = 4, all conditions). Significant differences were determined by Student's t-test. Error bars indicate standard error of the mean.