STEPP analysis of 5-year disease-free survival according to level of composite measure of prognostic risk. Plots include the 5,177 assessable patients enrolled in the four-arm option at a median follow-up of 71 months. (a) Treatment groups combined and (b) according to randomized treatment group. Rug plots along the x-axis display the distribution of individual values. DFS, disease-free survival; Let, letrozole; STEPP, Subpopulation Treatment Effect Pattern Plot; Tam, tamoxifen. Reprinted with permission from Annals of Oncology . Copyright 2011, Oxford University Press.