Figure 1From: Interpreting breast international group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancerDesign of the Breast International Group 1-98 trial. The design allows both head-to-head comparison of letrozole monotherapy versus tamoxifen monotherapy (4,922 patients) and assessment of the role of sequential endocrine treatments (6,182 patients). Neoadj CT, neoadjuvant chemotherapy.Back to article page