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Table 1 Baseline characteristics of 105 patients

From: Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis

Characteristics Total
No. of Pt (%)
Low Ki-67
No. of Pt (%)
High Ki-67 a
No. of Pt (%)
P-value
Median age (range)     
   Age <35 years 18 (17.1) 5 (17.9) 13 (16.9) 0.907
   Age ≥35 years 87 (82.9) 23 (82.1) 64 (83.1)  
Performance status     
   ECOG 0 25 (23.8) 7 (25.0) 18 (23.4) 0.686
   ECOG 1 78 (74.3) 21 (75.0) 57 (74.0)  
   ECOG 2 2 (1.9) 0 (0.0) 2 (2.6)  
Pathologic characteristics     
   Invasive ductal carcinoma 101 (96.2) 28 (100.0) 73 (94.8) 0.572
   Others 4 (3.8) 0 (0.0) 4 (5.2)  
Initial clinical stage     
   IIA 4 (3.8) 1 (3.6) 3 (3.9) 0.985
   IIB 19 (18.1) 5 (17.9) 14 (18.2)  
   IIIA 45(42.9) 11 (39.3) 34 (44.2)  
   IIIB 18 (17.1) 5 (17.9) 13 (16.9)  
   IIIC 19 (18.1) 6 (21.4) 13 (16.9)  
Inflammatory breast cancer     
   No 97 (92.4) 25 (89.3) 72 (93.5) 0.437
   Yes 8 (7.6) 3 (10.7) 5 (6.5)  
Type of surgery     
   Breast conserving 44 (41.9) 13 (46.4) 31 (40.3) 0.571
   Mastectomy 61 (58.1) 15 (53.6) 46 (59.7)  
Radiation therapy     
   No 11 (10.5) 2 (7.1) 9 (11.7) 0.723
   Yes 94 (89.5) 26 (92.9) 68 (88.3)  
Nuclear grade     
   I 1(1.0) 0 (0.0) 1 (1.3) 0.260
   II 7 (6.7) 2 (7.1) 5 (6.5)  
   III 88 (73.3) 24 (85.7) 53 (68.8)  
   Unknown 20 (19.0) 2 (7.1) 18 (23.4)  
Histologic grade     
   I 0 (0.0) 0 (0.0) 0 (0.0) 0.097
   II 23 (21.9) 10 (35.7) 13 (16.9)  
   III 74 (70.5) 17 (60.7) 57 (74.0)  
   Unknown 8 (7.6) 1 (3.6) 7 (9.1)  
bcl-2     
   Negative 66 (62.9) 15 (53.6) 51 (66.2) 0.235
   Positive 39 (37.1) 13 (46.4) 26 (33.8)  
p53     
   Negative 39 (37.1) 12 (42.9) 27 (35.1) 0.657
   Positive 65 (61.9) 16 (57.1) 49 (63.6)  
   Unknown 1 (1.0) 0 (0.0) 1 (1.3)  
pCR     
   No 91 (86.7) 28 (100.0) 86 (81.8) 0.019
   Yes 14 (13.3) 0 (0.0) 14 (18.2)  
  1. Abbreviations: ECOG, Eastern Cooperative Oncology Group; pCR, pathologic complete response.
  2. a High Ki-67 expression was defined as ≥10%