Cell line | ER status | Genotype | BGT226 (nmol/l) | BKM120 (nmol/l) | RAD001 (nmol/l) | |||
---|---|---|---|---|---|---|---|---|
 |  |  | LC50 | IC50 | LC50 | IC50 | LC50 | IC50 |
MCF7 | Positive | PIK3CA E545K | 7.5 | 3.5 | 3,981 | 248 | >625 | >625 |
T47D | Positive | PIK3CA H1047R | 10 | 2.7 | 316 | 128 | >625 | 1.5 |
HCC712 | Positive | PIK3CB amp | 549 | >625 | >10,000 | 347 | >625 | >625 |
MCF7 LTED | Positive | PIK3CA E545K | 398 | 1.18 | 2,691 | 70.7 | >625 | <1 |
MCF7 LTED-R | Positive | PIK3CA E545K | 617 | 5.1 | >10,000 | 4,926 | >625 | >625 |
T47D LTED | Negativea | PIK3CA H1047R | 19 | 2.3 | 630 | 243 | >625 | <1 |
BT-483 | Positive | PIK3CA E542K | 2.5 | 7.05 | >10,000 | >10,000 | >625 | <1 |
MDA-MB-415 | Positive | PTEN mut | 28.1 | <1 | 1,584 | 1,294 | >625 | >625 |
CAMA-1 | Positive | PTEN mut | 275 | 46.2 | >10,000 | >10,000 | >625 | <1 |
ZR75-1 | Positive | PTEN mut | 1.3 | <1 | 363 | 207 | >625 | <1 |
HCC1428 | Positive | PIK3CA/PTEN wt | 501 | >625 | 1,258 | 1,138 | 3.1 | <1 |
MDA-MB-175 | Positive | PIK3CA/PTEN wt | >625 | <1 | 5,011 | >10,000 | >625 | <1 |
MDA-MB-231 | Negative | K-Ras, B-Raf mut | >625 | <1 | >10,000 | 1,237 | >625 | >625 |