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Figure 7 | Breast Cancer Research

Figure 7

From: Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer

Figure 7

Fulvestrant and estradiol treatment sensitize long-term estrogen-deprived cells to phosphatidylinositol-3-kinase inhibitors. Estrogen-deprived (a) MCF7 and MCF7 long-term estrogen deprivation (LTED) cells or (b) T47D and T47D LTED cells were treated with fulvestrant, estradiol (E2) or phosphatidylinositol-3-kinase (PI3K) pathway inhibitors as indicated and apoptosis was measured after 4 days of treatment. Results are from at least three replicates for each treatment condition. Abrogation of E2 rescue or potentiation of PI3K inhibitor-induced apoptosis by fulvestrant is indicated (*P < 0.05). (c) Estrogen-deprived MCF7, MCF7 LTED and MCF7 estrogen-retreated long-term estrogen-deprived (LTED-R) cells were treated with the indicated concentrations of BGT226 and apoptosis was measured after 4 days of treatment. Results are from at least three replicates for each treatment condition. Significant activation of apoptosis is indicated (*P < 0.05). (d) MCF7, MCF7 LTED and MCF7 LTED-R cells were treated with E2, BGT226, BKM120 or RAD001 as indicated and apoptosis was measured after 4 days. Results are from at least three replicates for each treatment condition. Significant activation of apoptosis with respect to untreated control cells is indicated (*P < 0.05).

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