The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

Table 3 Multivariate analysis in the combined cohort (N = 378)

Characteristic	P value	Hazard ratio	95% CI for hazard ratios
Tumor type
Luminal (reference)	0.09
Basal	0.02	4.04	1.3 to 12.8
HER2	0.15	1.64	0.8 to 3.2
Null	0.67	1.23	0.5 to 3.2
Grade
1	0.000
2	0.02	2.61	1.2 to 5.8
3	0.0001	12.72	5.2 to 31.4
Lymph node status	0.28	0.75	0.4 to 1.3
Tumor size >20 mm	0.18	0.69	0.4 to 1.2

Multivariate analysis using a binary logistic regression model of the effect of SIAH2 expression on tumor subtype (with luminal tumors as a reference), tumor grade, lymph node status and tumor size
^aaSIAH2, seven in absentiahomolog 2 gene.
95% CI, 95% confidence interval; HER2, human epidermal growth factor receptor 2.

ISSN: 1465-542X