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Table 1 Tamoxifen Insensitive genes supported by the Apo-ER -> Apo-RARα Axis

From: During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein

Gene

ATRA effect

RARa binding <10 kb

Fold change siER

Fold change siRARα1

Gene

ATRA effect

RARa binding <10 kb

Fold change siER

Fold change siRARα1

LGALS1

-

0.31

0.46

CASC5

-

-

0.47

0.51

METTL7A

-

0.37

0.53

BIRC5

-

-

0.53

0.48

CDKN3

-

0.44

0.60

PTTG1

-

-

0.57

0.54

XK

-

0.46

0.54

PLK4

-

-

0.56

0.49

GHR

-

0.41

0.57

CENPA

-

-

0.58

0.56

YPEL1

-

0.58

0.54

TMSB15A

-

-

0.42

0.41

SHANK2

++

0.58

0.57

C5

-

-

0.38

0.48

ENY2

-

++

0.54

0.45

CDC2

-

-

0.56

0.59

ONECUT2

-

++

0.50

0.58

CCNA2

-

-

0.59

0.52

HIST1H4C

-

++

0.21

0.31

LOC150759

-

-

0.49

0.59

NCAPH

-

++

0.47

0.53

NCAPG

-

-

0.50

0.51

CENPN

-

++

0.56

0.55

CENPM

-

-

0.57

0.50

UBE2T

-

++

0.53

0.60

FAM64A

-

-

0.55

0.58

PHF19

-

++

0.50

0.50

MND1

-

-

0.51

0.55

ZNF367

-

++

0.52

0.51

FGFR1

-

-

0.56

0.53

SNORA72

-

++

0.43

0.58

HELLS

-

-

0.58

0.55

KIF23

-

+

0.58

0.56

TNFAIP8L1

-

-

0.47

0.55

ENAH

-

+

0.54

0.50

OVOS2

-

-

0.40

0.58

MAD2L1

-

+

0.40

0.55

ZNF141

-

-

0.55

0.52

SMC4

-

+

0.54

0.60

LOC100129673

-

-

0.39

0.48

SEC31A

-

+

0.55

0.57

ASPM

-

-

0.45

0.45

SFPQ

-

+

0.60

0.49

EPHX4

-

-

0.51

0.55

CENPF

-

+

0.51

0.58

HNRPD

-

-

0.36

0.55

COBL

-

-

0.54

0.52

ARPC5L

-

-

0.59

0.52

PBK

-

-

0.56

0.56

RGS3

-

-

0.57

0.45

MLF1IP

-

-

0.44

0.58

SIPA1L1

-

-

0.55

0.58

SAMHD1

-

-

0.60

0.53

     
  1. a RAR binding site identified within 10 kb of the transcription start site (Hua et al., 2009).
  2. ++ RAR binding site detected under high stringency (Hua et al., 2009).
  3. + RAR binding site detected under low stringency (Hua et al., 2009).
  4. ↑ Up-regulated by ATRA (1 μM, 24 h) ≥2-fold.
  5. ↓ Down-regulated by ATRA (1 μM, 24 h) ≤50%.
  6. Abbreviations: ER, estrogen receptor; RAR, retinoic acid receptor; ATRA, all trans-retinoic acid; si, small interfering RNA.