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Table 5 Pair-wise interaction between SNPs within PPARGC1B and ESR1 on ER-positive breast cancer in combined Swedish and Finnish samples

From: Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer

ESR1(rs7761846) PPARGC1B
  Cases (%) Controls (%) OR (95% CI) Cases (%) Controls (%) OR (95% CI)
  GG (rs2340621) GA/AA (rs2340621)
TT 916 (39) 1,121 (42) 1 1,160 (50) 1,280 (48) 1.18 (1.03, 1.34)
CT/CC 106 (5) 151 (6) 0.95 (0.71, 1.29) 161 (7) 134 (5) 1.94 (1.47, 2.55)
Interaction P valuea 0.008      
  GG (rs6895698) GA/AA (rs6895698)
TT 1,284 (55) 1,566 (58) 1 791 (34) 837 (31) 1.28 (1.11, 1.47)
CT/CC 160 (7) 184 (7) 1.21 (0.93, 1.55) 106 (5) 101 (4) 1.77 (1.30, 2.42)
Interaction P valuea 0.506      
  GG (rs741581) GA/AA (rs741581)
TT 1,741 (74) 2,076 (77) 1 335 (14) 326 (12) 1.41 (1.17, 1.70)
CT/CC 225 (10) 251 (9) 1.25 (1.01, 1.55) 42 (2) 34 (1) 2.18 (1.32, 3.59)
Interaction P valuea 0.459      
  1. OR, odds ratio; CI, confidence interval. aAnalysis was performed on combined dataset, in which study and age were regarded as covariables.