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Table 5 Pair-wise interaction between SNPs within PPARGC1B and ESR1 on ER-positive breast cancer in combined Swedish and Finnish samples

From: Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer

ESR1(rs7761846)

PPARGC1B

 

Cases (%)

Controls (%)

OR (95% CI)

Cases (%)

Controls (%)

OR (95% CI)

 

GG (rs2340621)

GA/AA (rs2340621)

TT

916 (39)

1,121 (42)

1

1,160 (50)

1,280 (48)

1.18 (1.03, 1.34)

CT/CC

106 (5)

151 (6)

0.95 (0.71, 1.29)

161 (7)

134 (5)

1.94 (1.47, 2.55)

Interaction P valuea

0.008

     
 

GG (rs6895698)

GA/AA (rs6895698)

TT

1,284 (55)

1,566 (58)

1

791 (34)

837 (31)

1.28 (1.11, 1.47)

CT/CC

160 (7)

184 (7)

1.21 (0.93, 1.55)

106 (5)

101 (4)

1.77 (1.30, 2.42)

Interaction P valuea

0.506

     
 

GG (rs741581)

GA/AA (rs741581)

TT

1,741 (74)

2,076 (77)

1

335 (14)

326 (12)

1.41 (1.17, 1.70)

CT/CC

225 (10)

251 (9)

1.25 (1.01, 1.55)

42 (2)

34 (1)

2.18 (1.32, 3.59)

Interaction P valuea

0.459

     
  1. OR, odds ratio; CI, confidence interval. aAnalysis was performed on combined dataset, in which study and age were regarded as covariables.
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Breast Cancer Research

ISSN: 1465-542X

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