Skip to main content

Table 2 Twenty-five most significant SNPs associated with ER-positive breast cancer in Swedish and Finnish samples

From: Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer

Gene

SNP

Position

Pvaluea

Adjusted Pvalueb

OR (95% CI)a

PPARGC1B

rs741581cd

chr5:149182978

4.84 × 10-5

0.033

1.414 (1.197, 1.672)

PPARGC1B

rs1012543cd

chr5:149157138

9.98 × 10-5

0.067

1.223 (1.105, 1.353)

PPARGC1B

rs6895698d

chr5:149120455

2.73 × 10-4

0.184

1.225 (1.098, 1.366)

CARM1

rs1529711

chr19:10884434

4.26 × 10-4

0.288

1.229 (1.096, 1.378)

RBM23

rs7469 c

chr14:22440037

1.15 × 10-3

0.778

1.248 (1.092, 1.427)

PPARGC1B

rs4705365cd

chr5:149093146

1.78 × 10-3

-

1.193 (1.068, 1.333)

NCOR2

rs10846670

chr12:123456184

2.67 × 10-3

-

0.872 (0.798, 0.954)

RBM23

rs3811187c

chr14:22439134

2.96 × 10-3

-

1.158 (1.051, 1.275)

PELP1

rs4790674

chr17:4529772

3.23 × 10-3

-

1.171 (1.054, 1.3)

PPARGC1B

rs2340621d

chr5:149122509

4.00 × 10-3

-

1.149 (1.045, 1.262)

CCND1

rs649392cd

chr11:69173974

4.43 × 10-3

-

0.877 (0.801, 0.96)

PPARGC1B

rs10036538d

chr5:149135781

5.51 × 10-3

-

1.156 (1.043, 1.28)

PELP1

rs7214635

chr17:4547769

5.67 × 10-3

-

1.166 (1.046, 1.3)

PPARGC1B

rs4705382

chr5:149161559

6.32 × 10-3

-

0.872 (0.791, 0.962)

NEDD4

rs11071224c

chr15:53902817

6.32 × 10-3

-

0.764 (0.63, 0.927)

MED13

rs4968469c

chr17:57491867

6.90 × 10-3

-

1.145 (1.038, 1.263)

NCOR2

rs12321007

chr12:123449054

7.44 × 10-3

-

1.137 (1.035, 1.25)

MED13

rs9889324c

chr17:57481404

8.89 × 10-3

-

1.14 (1.033, 1.258)

NCOR2

rs1794973

chr12:123391545

9.45 × 10-3

-

0.889 (0.813, 0.972)

PPARGC1B

rs1422429

chr5:149146627

1.11 × 10-2

-

1.124 (1.027, 1.231)

NCOR2

rs10846666

chr12:123450306

1.17 × 10-2

-

0.867 (0.776, 0.969)

NCOA1

rs17046513

chr2:24817999

1.26 × 10-2

-

1.284 (1.055, 1.563)

NCOA1

rs17046462

chr2:24759054

1.37 × 10-2

-

1.285 (1.053, 1.568)

NCOR2

rs10846667

chr12:123450377

1.40 × 10-2

-

0.895 (0.819, 0.978)

SNW1

rs3759728c

chr14:77299912

1.49 × 10-2

-

0.855 (0.753, 0.97)

  1. ER, estrogen receptor; chr, chromosome; OR, odds ratio; CI, confidence interval. aP value and OR were obtained from meta-analysis based on the inverse variance method for two independent datasets. The individual OR was obtained from age-unadjusted analysis in the Swedish sample and age-adjusted analysis in the Finnish sample. bP value was adjusted by Bonferroni correction (n = 675); -, adjusted P > 1. cSNP belongs to the top 25 most significant SNPs associated with ER-negative breast cancer. dSNP was significantly associated with ER-positive breast cancer in both the Swedish and Finnish datasets.