Figure 1

Transcriptional regulation of PPARGC1B by estrogen receptor alpha in the MCF7 cell line. (A) Schematic diagram of the genes from the UCSC database. (B) Map positions of six significant SNPs within PPARGC1B. (C) Recombination rate surrounding PPARGC1B from the HapMap CEU database. (D) MCF7 input DNA density for chromatin immunoprecipitation-sequencing (CHIP-seq) analysis. (E) CHIP-seq RNA PolII occupancy density without 17β-estradiol (E2) treatment. (F) CHIP-seq estrogen receptor (ER) occupancy without E2 treatment. (G) CHIP-seq RNA PolII occupancy density with E2 treatment. (H) CHIP-seq ER occupancy with E2 treatment. (I) ER interaction loop detected by chromatin interaction analysis by paired-end tag sequencing (ChIA-PET).