Table 1 Reported changes quantified on functional magnetic resonance following neoadjuvant chemotherapy for breast cancer
From: Functional magnetic resonance: biomarkers of response in breast cancer
Functional technique and study | Responders | Non-responders | Time point imaged after NAC |
|---|---|---|---|
DCE-MRI (percentage change in parameters) | Â | Â | Â |
   Ah-See et al. [12] | Ktrans ↓39.8% | Ktrans ↑18.1% | 2 cycles |
|  | kep ↓33.3% | kep ↑7.4% | 2 cycles |
|  | rBV ↓59.3% | rBV ↑73.4% | 2 cycles |
|  | rBF ↓56.4% (n = 19) | rBF ↑70.6% (n = 19) | 2 cycles |
   Pickles et al. [13] | Ktrans ↓19.7% | Ktrans ↓19.6% | 'At early time point' |
|  | kep ↓19.9% | kep ↓36.2% |  |
|  | ve ↑4.36% (n = 48) | ve ↑27.6% (n = 20) |  |
   Padhani et al. [15] | Ktrans ↓22% (n = 9) | Ktrans ↓6.5% (n = 6) | 1 cycle |
|  | Ktrans ↓62% (n = 7) | Ktrans ↓25% (n = 6) | 2 cycles |
DW-MRI (percentage change in ADC) | Â | Â | Â |
   Pickles et al. [32] | ↑16% (n = 10) | NA | 1 cycle |
|  | ↑27% (n = 10) | NA | 2 cycles |
   Sharma et al. [33] | ↑15% (n = 14) | NA | 1 cycle |
|  | ↑27% (n = 24) | NA | 2 cycles |
|  | ↑35% (n = 29) | NA | 3 cycles |
   Nilsen et al. [34] | ↑25% (n = 25) | NA | 4 cycles |
R 2 * (change in s -1 ) | Â | Â | Â |
   Li et al. [36] | ↑10% (n = 27) | NA | 2 cycles |
MRS (percentage change in Cho SNR) | Â | Â | Â |
   Jacobs et al. [46] | ↓35% (n = 15) | ↓11% (n = 3) | 1 cycle |
23 Na MRI (percentage change in total sodium concentration) | Â | Â | Â |
   Jacobs et al. [46] | ↓27% (n = 15) | ↓21% (n = 3) | 1 cycle |