Skip to main content

Table 1 Reported changes quantified on functional magnetic resonance following neoadjuvant chemotherapy for breast cancer

From: Functional magnetic resonance: biomarkers of response in breast cancer

Functional technique and study Responders Non-responders Time point imaged after NAC
DCE-MRI (percentage change in parameters)    
   Ah-See et al. [12] Ktrans ↓39.8% Ktrans ↑18.1% 2 cycles
  kep ↓33.3% kep ↑7.4% 2 cycles
  rBV ↓59.3% rBV ↑73.4% 2 cycles
  rBF ↓56.4% (n = 19) rBF ↑70.6% (n = 19) 2 cycles
   Pickles et al. [13] Ktrans ↓19.7% Ktrans ↓19.6% 'At early time point'
  kep ↓19.9% kep ↓36.2%  
  ve ↑4.36% (n = 48) ve ↑27.6% (n = 20)  
   Padhani et al. [15] Ktrans ↓22% (n = 9) Ktrans ↓6.5% (n = 6) 1 cycle
  Ktrans ↓62% (n = 7) Ktrans ↓25% (n = 6) 2 cycles
DW-MRI (percentage change in ADC)    
   Pickles et al. [32] ↑16% (n = 10) NA 1 cycle
  ↑27% (n = 10) NA 2 cycles
   Sharma et al. [33] ↑15% (n = 14) NA 1 cycle
  ↑27% (n = 24) NA 2 cycles
  ↑35% (n = 29) NA 3 cycles
   Nilsen et al. [34] ↑25% (n = 25) NA 4 cycles
R 2 * (change in s -1 )    
   Li et al. [36] ↑10% (n = 27) NA 2 cycles
MRS (percentage change in Cho SNR)    
   Jacobs et al. [46] ↓35% (n = 15) ↓11% (n = 3) 1 cycle
23 Na MRI (percentage change in total sodium concentration)    
   Jacobs et al. [46] ↓27% (n = 15) ↓21% (n = 3) 1 cycle
  1. ADC, apparent diffusion coefficient; Cho, choline; DCE, dynamic contrast-enhanced; DW, diffusion-weighted; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; NA, sodium; NAC, neoadjuvant chemotherapy; rBF, relative blood flow; rBV, relative blood volume; SNR, signal-to-noise ratio.