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Table 6 Correlation of RAD21 gene expression with genomic alterations*

From: Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers

Subtype

Copy number

Pearson correlation

P-value

Gaina

Mann Whitney U test

P-value

Amplificationb

Mann Whitney U test

P-value

Luminal (n = 22)

0.0030

0.0169

0.0465

Basal-like (n = 13)

0.0086

--

0.0111

HER2 (n = 13)

0.0035

0.0503

0.1025

  1. * Patients and Methods were as described in Natrajan et al. (2009).
  2. a Gain corresponds to approximately three to five copies of the locus as defined using a smoothed Log2 ratio of between 0.08 and 0.45.
  3. b Amplification was defined as having a Log2 ratio > 0.45, corresponding to more than five copies.
  4. CGH, comparative genomic hybridization.