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Table 3 Genotypes and risk of AIAA1

From: Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors

Polymorphism

Genotype frequency

AIAA

 

Genotype

% (N)

% (N)

P-value2

 

C/C

28.1 (107)

50 (54)

 

3' UTR C/T (rs10046)

C/T

47.8 (182)

54 (98)

0.20

 

T/T

24.1 (92)

42 (39)

 
 

G/G

30.8 (118)

54 (63)

 

IVS1 A/G (rs749292)

G/A

52.2 (200)

48 (96)

0.57

 

A/A

17.0 (65)

54 (35)

 
 

G/G

13.1 (50)

50 (25)

 

IVS2 G/T (rs727479)

G/T

42.7 (163)

52 (84)

0.94

 

T/T

44.2 (169)

50 (84)

 
 

TCT/TCT

44.8 (172)

49 (84)

 

IVS4 -/TCT (rs11575899)

TCT/-

41.4 (159)

51 (81)

0.86

 

-/-

13.8 (53)

53 (28)

 
 

No 7 repeat

28.8 (109)

42 (46)

0.03

 

Any 7 repeat

71.2 (270)

55 (148)

 
 

No 8 repeat

87.1 (330)

53 (176)

0.03

 

Any 8 repeat

12.9 (49)

37 (18)

 

(TTTA)n (rs60271534)

No 10 repeat

88.7 (336)

51 (173)

0.75

 

Any 10 repeat

11.3 (43)

49 (21)

 
 

No 11 repeat

62.2 (234)

52 (121)

0.92

 

Any 11 repeat

37.8 (142)

51 (72)

 
 

No 12 repeat

88.7 (336)

51 (170)

0.63

 

Any 12 repeat

11.3 (43)

56 (24)

 
  1. Abbreviations: AIAA, Aromatase Inhibitor Associated Arthralgia.
  2. 1Among Caucasian subjects.
  3. 2Chi-square.