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Table 4 Results from logistic regression tests for loglinear odds ratio trendsa

From: Rare, evolutionarily unlikely missense substitutions in CHEK2contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study

  Loglinear OR regression coefficient (95% CI) and Pvalue
Grouping of rMS and/or T+SJV Crude Adjustedb
rMS only (that is, excluding T+SJV) 0.35 (0.12 to 0.58) 0.33 (0.09 to 0.55)
   (note that C65 is grade 7)    P = 0.0029    P = 0.0055
C65 rMS and T+SJV 0.28 (0.14 to 0.43) 0.29 (0.14 to 0.43)
   pooled in grade 7    P = 0.00013    P = 0.000088
C65 rMS in grade 7 and 0.26 (0.12 to 0.39) 0.26 (0.13 to 0.40)
   T+SJV in grade 8    P = 0.00017    P = 0.00011
  1. a OR, odds ratio; 95% CI, 95% confidence interval; rMS, rare missense substitution; T+SJV, protein-truncating variants plus splice junction variant; bAdjusted for race or ethnicity (Caucasian, East Asian, African American or Latina), study center and age as categorical variables.