Rare, evolutionarily unlikely missense substitutions in CHEK2contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study

Table 4 Results from logistic regression tests for loglinear odds ratio trends^a

	Loglinear OR regression coefficient (95% CI) and Pvalue
Grouping of rMS and/or T+SJV	Crude	Adjusted^b
rMS only (that is, excluding T+SJV)	0.35 (0.12 to 0.58)	0.33 (0.09 to 0.55)
(note that C65 is grade 7)	P = 0.0029	P = 0.0055
C65 rMS and T+SJV	0.28 (0.14 to 0.43)	0.29 (0.14 to 0.43)
pooled in grade 7	P = 0.00013	P = 0.000088
C65 rMS in grade 7 and	0.26 (0.12 to 0.39)	0.26 (0.13 to 0.40)
T+SJV in grade 8	P = 0.00017	P = 0.00011

^a OR, odds ratio; 95% CI, 95% confidence interval; rMS, rare missense substitution; T+SJV, protein-truncating variants plus splice junction variant; ^bAdjusted for race or ethnicity (Caucasian, East Asian, African American or Latina), study center and age as categorical variables.

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