Figure 5
From: α-Tocopheryloxyacetic acid: a novel chemotherapeutic that stimulates the antitumor immune response
α-TEA-mediated tumor suppression has a T cell-dependent component. BALB/c mice with established 4T1 mammary tumors were depleted of T cells by intraperitoneal injection of CD4- and/or CD8-specific antibodies and received α-TEA in their diet (~6 mg/day, equivalent to 300 mg/kg body wt). Immunocompetent animals (not depleted) received isotype antibody and α-TEA. Kaplan-Meier analysis of survival is shown (n = 7 mice per group).