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Table 2 Regulated mRNAs in BC cells after miR-2 1 knockdown determined by oligo array

From: Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivotumor growth

    

Fold change

 

Gene Name

NCBI accession number

Genbank accession number

Description

MCF-7

MDA-MB-231

Prediction program

ANKRD46

NM_198401

U79297, BC035087

ankyrin repeat domain 46

1.78

2.57 #

miRBase Targets V5

ACTN4

NM_004924

BC005033

Alpha-actin 4 (F-actin cross linking protein)

1.75

1.55

 

NR0B1

NM_000475

S74720

Nuclear receptor 0B1 (Nuclear receptor DAX-1)

1.60

1.32

 

HIRA

NM_003325

BC039835, X89887

HIRA protein

1.48

1.32

 

COL18A1

NM_030582, NM_130444, NM_130445

AF018081

Collagen alpha 1(XVIII) chain precursor

1.43

1.35

 

SAMD11

NM_152486

BC024295, AK054643

sterile alpha motif domain containing 11

1.42

1.34

 

EIF4A2

NM_001967

AL117412

Eukaryotic initiation factor 4A-II

1.42

1.41

miRNAMap

SFRS16

NM_007056

AF042800, AK094681

Splicing factor, arginine/serine-rich 16

1.40

1.34

 

NP_079316

-

BC004930

zinc finger protein 614

1.37

1.36

 

IL18BP

NM_173043, NM_005699, NM_173042

AF110801

Interleukin-18 binding protein precursor

1.36

1.34

 

GBF1

NM_004193

AK025330, AF068755

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1.35

1.51

 

GNPDA1

NM_005471

AJ002231

Glucosamine-6-phosphate isomerase

1.34

1.32

 

SPUF_HUMAN

NM_013349

-

SPUF protein precursor

1.34

1.31

 

PLXNA1

NM_032242

AK127254

plexin A1; plexin 1

1.32

1.57

 

STMN3

NM_015894

AK094112

Stathmin 3 (SCG10-like protein)

1.32

1.47

 

NP_056236

NM_015421

AK093383, AL080088

DKFZP564K2062 protein

1.31

1.33

 

-

-

AK056473

-

1.31

1.30

 

AP2B1

NM_001282

M34175

adaptor-related protein complex 2, beta 1 subunit

1.31

1.45

 

HIST1H2AC

-

CR608156

Histone H2A.l (H2A/l)

-1.47

-1.67

 

PRKCI

NM_002740

L33881, BC042405, BC022016

Protein kinase C, iota type

-1.43

-1.32

 

SLC25A3

NM_002635, NM_213611, NM_213612, NM_005888

BX647062, AK057575

Phosphate carrier protein, mitochondrial precursor (PTP)

-1.39

-1.39

 

CCNE1

NM_057182, NM_001238

M74093, BC035498

G1/S-specific cyclin E1

-1.37

-1.39

 

DCAMKL1

NM_004734

AB002367

Serine/threonine-protein kinase DCAMKL1

-1.34

-1.46

 

GNG12

NM_018841

AL832431

Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-12 subunit

-1.32

-1.40

Miranda

Q8TAY7

NM_024869

BC025658

hypothetical protein FLJ14050

-1.32

-1.31

 

NP_653284

NM_144683

BC015582

hypothetical protein MGC23280

-1.31

-1.35

 

NP_055182

NM_014367

-

growth and transformation-dependent protein

-1.30

-1.34

 
  1. Fold-regulation of mRNAs affected by miR-21 knockdown compared with control-transfected cells (MCF-7 and MDA-MB-231) at indicated time points. Fold-changes for all mRNAs are derived from a single microarray experiment, with two relevant genes confirmed by qRT-PCR (Figure 4B). Shown are mRNAs changing by at least 1.3-fold in both cell lines. Genes in bold were selected for candidate gene analyses by qRT-PCR.; # marginal signal intensity; NCBI, National Center for Biotechnology Information; GB, GenBank.
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Breast Cancer Research

ISSN: 1465-542X

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