The Kaplan-Meier survival curves for PALB2 c.3113G > A mutation carriers. The Kaplan-Meier survival curve with breast cancer as the outcome for female first- and second-degree relatives of the probands with the fitted survival curve overlaid. The fitted survival curve was calculated as the average of the survival curves for carriers and noncarriers, each of these being equal to the exponential minus the appropriate cumulative incidences. For the averaging of survival curves, we used age-specific weights equal to the expected proportion of relatives at risk of breast cancer at a given age who carry (for the carrier survival curve) or do not carry (for the noncarrier survival curve) the partner and localizer of breast cancer 2 susceptibility protein (PALB2) mutation. Carrier probabilities for the relatives were calculated from known genotypes and family relationships, but not from affected status or other phenotypes, using a modified version of Mendel 3.2 software .