From: Risk factors for ductal and lobular breast cancer: results from the nurses' health study
 | Ductal (n= 4,655) | Lobular (n= 659) |  | ||
---|---|---|---|---|---|
Reproductive or hormonal exposures | Cases (n) | RR (95% CI) | Cases (n) | RR (95% CI) | P-heterogeneityb |
Age (per year)c | 4,655 | 1.03 (1.03-1.04) | 659 | 1.04 (1.03-1.06) | 0.18 |
Age at menarche (per year)c | 4,655 | 0.98 (0.96-1.00) | 659 | 0.92 (0.87-0.97) | 0.03 |
Parous | 4,220 | 1.00 (ref) | 610 | 1.00 (ref) | Â |
Nulliparous | 437 | 1.26 (1.12-1.41) | 49 | 1.22 (0.87-1.71) | 0.87 |
Age at first birth (AFB) | Â | Â | Â | Â | Â |
   AFB < 25 | 2,354 | 1.00 (ref) | 268 | 1.00 (ref) |  |
   AFB 25-29 | 1,741 | 1.11 (2.04-1.19) | 282 | 1.63 (1.37-1.96) |  |
   AFB 30-34 | 425 | 1.21 (1.09-1.35) | 86 | 2.31 (1.79-2.99) |  |
   AFB ≥35 | 137 | 1.31 (1.10-1.57) | 23 | 2.10 (1.35-3.26) | <0.001 |
   AFB, continuous, RR (P trend)c |  | 1.12 (<0.001) |  | 1.48 (<0.001) | <0.001 |
Parity | Â | Â | Â | Â | Â |
   Parity = 1 | 813 | 1.00 (ref) | 100 | 1.00 (ref) |  |
   Parity = 2 | 1,171 | 0.99 (0.91-1.07) | 180 | 0.94 (0.76-1.16) |  |
   Parity = 3 | 1,269 | 1.04 (0.96-1.13) | 163 | 0.88 (0.71-1.09) |  |
   Parity ≥ 4 | 1,404 | 0.91 (0.82-1.00) | 216 | 0.96 (0.75-1.24) | 0.35 |
   Parity, continuous, RR (P trend)d |  | 0.97 (0.01) |  | 1.05 (0.11) | 0.02 |
Postmenopausal hormone use | Â | Â | Â | Â | Â |
   Never used | 1,616 | 1.00 (ref) | 181 | 1.00 (ref) |  |
   Past use | 1,165 | 1.05 (0.97-1.14) | 150 | 1.11 (0.88-1.39) |  |
   Current use, estrogen alone < 5 years | 143 | 1.07 (0.90-1.28) | 24 | 1.56 (1.01-2.42) |  |
   Current use, estrogen plus progesterone < 5 years | 283 | 1.56 (1.36-1.78) | 42 | 2.16 (1.52-3.06) |  |
   Current use, other ≤10 years | 267 | 1.31 (1.15-1.49) | 46 | 1.95 (1.40-2.71) |  |
   Current use, estrogen alone 5-10 years | 518 | 1.30 (1.17-1.45) | 93 | 1.76 (1.34-2.34) |  |
   Current use, estrogen + progesterone 5-10 years | 463 | 1.75 (1.57-1.95) | 99 | 3.12 (2.41-4.05) | <0.001 |
   Estrogen alone, continuous, RR (P trend)e |  | 1.00 (0.008) |  | 1.00 (0.24) | 1.00 |
   Estrogen + progesterone, continuous, RR (P trend)e |  | 1.02 (<0.001) |  | 1.03 (<0.001) | 0.43 |
   Other, continuous, RR (P trend)e |  | 1.00 (0.45) |  | 1.01 (0.30) | 0.52 |
Age at menopause (per year)c | 4,655 | 1.01 (1.00-1.01) | 659 | 1.01 (1.00-1.02) | 0.45 |
Menopausal type | Â | Â | Â | Â | Â |
   Natural or radiation-induced | 2,958 | 1.00 (ref) | 391 | 1.00 (ref) |  |
   Surgical with two ovaries removed | 667 | 0.80 (0.73-0.89) | 101 | 1.00 (0.78-1.29) |  |
   Surgical with one or no ovaries removed | 559 | 0.87 (0.79-0.96) | 100 | 1.21 (0.95-1.53) | 0.08 |
Nonreproductive exposures | Â | Â | Â | Â | Â |
Body mass index (BMI) | Â | Â | Â | Â | Â |
   <21 | 473 | 1.00 (ref) | 70 | 1.00 (ref) |  |
   21 to less than 23 | 719 | 1.15 (1.02-1.29) | 104 | 1.11 (0.82-1.50) |  |
   23 to less than 25 | 858 | 1.21 (1.08-1.35) | 122 | 1.14 (0.85-1.54) |  |
   25 to less than 30 | 1,590 | 1.41 (1.27-1.57) | 225 | 1.33 (1.01-1.75) |  |
   ≥30 | 926 | 1.60 (1.42-1.80) | 124 | 1.47 (1.08-2.00) | 0.20 |
   BMI, continuous, RR (P trend)f |  | 1.14 (<0.001) |  | 1.12 (0.009) | 0.75 |
BMI at age 18 | Â | Â | Â | Â | Â |
   <19 | 839 | 1.07 (0.98-1.16) | 114 | 1.00 (0.79-1.25) |  |
   19 to less than 21 | 1,506 | 1.00 (ref) | 221 | 1.00 (ref) |  |
   21 to less than 23 | 959 | 0.83 (0.77-0.90) | 148 | 0.88 (0.71-1.09) |  |
   ≥23 | 744 | 0.74 (0.67-0.81) | 99 | 0.69 (0.54-0.88) | 0.16 |
   BMI at age 18, continuous, RR (P trend)f |  | 0.77 (<0.001) |  | 0.78 (0.003) | 0.80 |
Alcohol intake (g/day) | Â | Â | Â | Â | Â |
   0 | 2,552 | 1.00 (ref) | 334 | 1.00 (ref) |  |
   <5 | 876 | 1.15 (1.06-1.24) | 131 | 1.30 (1.05-1.59) |  |
   5 to less than 15 | 765 | 1.22 (1.12-1.32) | 113 | 1.34 (1.08-1.67) |  |
   ≥15 | 462 | 1.31 (1.19-1.45) | 81 | 1.75 (1.36-2.24) | 0.20 |
   Alcohol intake, continuous, RR (P trend)g |  | 1.04 (<0.001) |  | 1.07 (<0.001) | 0.11 |
Family history of breast cancer | Â | Â | Â | Â | Â |
   No | 3,805 | 1.00 (ref) | 544 | 1.00 (ref) |  |
   Yes | 850 | 1.55 (1.44-1.67) | 115 | 1.41 (1.15-1.73) | 0.39 |
Personal history of benign breast disease | Â | Â | Â | Â | Â |
   No | 2,294 | 1.00 (ref) | 298 | 1.00 (ref) |  |
   Yes | 2,361 | 1.47 (1.38-1.56) | 361 | 1.60 (1.37-1.88) | 0.32 |