Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study

Sieuwerts, Anieta M; Ansems, Marleen; Look, Maxime P; Span, Paul N; de Weerd, Vanja; van Galen, Anne; Foekens, John A; Adema, Gosse J; Martens, John WM

doi:10.1186/bcr2786

Table 3 Disease-free survival, metastasis-free survival, and overall survival as a function of continuous DC-SCRIPT in lymph node-negative disease

From: Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study

Association with continuous DC-SCRIPT		Disease-free survival				Metastasis-free survival				Overall survival
Cohort	Number	HR	95% CI		Pvalue	HR	95% CI		Pvalue	HR	95% CI		Pvalue
Lymph node-negative	837	0.82	0.73	0.93	0.001	0.77	0.67	0.88	< 0.001	0.82	0.72	0.94	0.005
ESR1 mRNA-negative^a	199	0.94	0.76	1.17	0.59	0.93	0.73	1.18	0.53	0.88	0.70	1.11	0.30
ESR1 mRNA-positive^a	638	0.79	0.68	0.90	0.001	0.72	0.62	0.85	< 0.001	0.81	0.69	0.96	0.014
PGR mRNA-negative^a	312	0.88	0.74	1.06	0.19	0.84	0.69	1.03	0.10	0.88	0.72	1.08	0.22
PGR mRNA-positive^a	525	0.81	0.69	0.94	0.007	0.75	0.63	0.89	0.001	0.82	0.68	0.99	0.04
ESR2 mRNA-low^a	410	0.76	0.64	0.91	0.003	0.69	0.56	0.84	< 0.001	0.73	0.64	0.97	0.026
ESR2 mRNA-high^a	410	0.93	0.78	1.11	0.43	0.89	0.73	1.09	0.26	0.92	0.75	1.13	0.41
Tumor size ≤ 2 cm (pT1)^b	378	0.74	0.61	0.89	0.001	0.67	0.54	0.83	0.000	0.73	0.59	0.91	0.005
Tumor size >2 cm^b	459	0.92	0.79	1.08	0.31	0.86	0.72	1.03	0.10	0.91	0.76	1.09	0.31
ESR1 mRNA-positive, tumor size ≤ 2 cm	306	0.69	0.56	0.85	0.001	0.61	0.48	0.78	< 0.001	0.72	0.56	0.93	0.010
ESR1 mRNA-positive, tumor size >2 cm	332	0.91	0.75	1.10	0.34	0.84	0.68	1.05	0.13	0.90	0.72	1.14	0.39
ESR2 mRNA-low, tumor size ≤ 2 cm	175	0.57	0.43	0.76	< 0.001	0.51	0.37	0.70	< 0.001	0.60	0.44	0.83	0.002
ESR2 mRNA-high, tumor size >2 cm	218	0.98	0.78	1.23	0.84	0.91	0.71	1.18	0.49	0.93	0.74	1.21	0.58
ESR1-positive and ESR2-low, tumor size ≤ 2 cm	147	0.63	0.45	0.87	0.005	0.54	0.38	0.78	< 0.001	0.63	0.43	0.92	0.017
ESR1-positive and ESR2-low, tumor size >2 cm	181	0.94	0.71	1.24	0.66	0.94	0.68	1.29	0.69	1.03	0.73	1.45	0.89
ESR1-positive or ESR2-low or both, tumor size ≤ 2 cm	334	0.65	0.53	0.79	< 0.001	0.57	0.46	0.71	< 0.001	0.67	0.53	0.84	0.001
ESR1-positive or ESR2-low or both, tumor size >2 cm	386	0.90	0.76	1.08	0.25	0.81	0.66	0.99	0.037	0.87	0.71	1.07	0.20

^aWith quantitative polymerase chain reaction cut point for positive versus negative ESR1 and PGR, 0.2 and 0.1, respectively, and for ESR2 at the median level of 0.005 (mRNA levels relative to reference gene set). ^bInteraction with continuous DC-SCRIPT (P < 0.05). CI, confidence interval; DC-SCRIPT, dendritic cell-specific transcript gene; ESR, estrogen receptor gene; HR, hazard ratio; PGR, progesterone receptor gene; pT1, small tumor without lymphatic/vascular invasion.

Back to article page

ISSN: 1465-542X

Contact us

Submission enquiries: journalsubmissions@springernature.com

Breast Cancer Research

Contact us