Table 2 Patient characteristics
From: Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2mutation carriers
Characteristic | BRCA1mutation carriers | BRCA2mutation carriers | ||
|---|---|---|---|---|
| Â | Unaffected | Breast cancer | Unaffected | Breast cancer |
Number of carriers | 2,193 | 2,531 | 1,189 | 1,504 |
Length of follow-up (person-years) | 93,521 | 102,870 | 53,147 | 66,764 |
Mean (SD) age at censure (years) | 43 (12.6) | 41 (9.4) | 45 (13.2) | 44 (9.7) |
Age at censure, n (%) | Â | Â | Â | Â |
   < 30 years | 344 (16%) | 252 (10%) | 144 (12%) | 52 (3%) |
   30 to 39 years | 658 (30%) | 1060 (42%) | 343 (29%) | 474 (32%) |
   40 to 49 years | 608 (28%) | 809 (32%) | 331 (28%) | 587 (39%) |
   50 to 59 years | 374 (17%) | 310 (12%) | 215 (18%) | 273 (18%) |
   60 to 69 years | 143 (6%) | 87 (3%) | 101 (8%) | 93 (6%) |
   70+ years | 66 (3%) | 13 (1%) | 55 (5%) | 25 (2%) |
Year of birth, n (%) | Â | Â | Â | Â |
   Before 1949 | 523 (24%) | 840 (33%) | 281 (24%) | 602 (40%) |
   1949 to 1959 | 508 (23%) | 816 (32%) | 307 (26%) | 518 (35%) |
   1960 to 1968 | 594 (27%) | 602 (24%) | 302 (25%) | 303 (20%) |
   After 1968 | 568 (26%) | 273 (11%) | 299 (25%) | 81 (5%) |
Oophorectomy | 260 (12%) | 77 (3%) | 126 (11%) | 47 (3%) |
Ethnicity, n (%) | Â | Â | Â | Â |
   Caucasian | 2127 (97%) | 2446 (97%) | 1159 (97%) | 1464 (97%) |
   Ashkenazi Jewish | 66 (3%) | 85 (3%) | 30 (3%) | 40 (3%) |