Figure 4

Deficiency of Mena decreases intravasation and metastasis to the lungs. A. Average number of circulating tumor cells in the blood of PyMT animals staged with carcinoma. Number of mice used of each genotype listed within bars. P-values listed above bars. Error bars indicate SEM. B. Average number of spontaneous lung metastases in PyMT animals staged with carcinoma. Number of mice used of each genotype listed within bars. P-values listed above bars. Error bars indicate SEM. C. Immunohistochemistry of lung metastases (indicated with black arrows) from the lungs of Mena WT, Het and Null mice. Images in the left column were taken at 50× (Scale bar = 200 μm), images in the right hand column were taken at 100× (Scale bar = 100 μm).