Figure 2

Deficiency of Mena slows progression to invasive carcinoma. A. Immunohistochemistry of normal mammary acinus from PyMT mouse at 10 weeks of age stained with Hematoxylin and Eosin. B. Immunohistochemistry of mammary gland tumors from PyMT Mena WT, Het and Null mice at 10 weeks of age stained with Hematoxylin and Eosin. Mammary glandular hyperplasia (i, ii, iii); Acini are not notably expanded in size (arrow). Mammary gland adenomas (iv, v, vi). Mammary carcinomas (vii, viii, ix). Scale bar = 100 μm. High magnification images showing some of the characteristics used to stage tumors are shown in Figure S2 in Additional file 1. C. Percent of mice with hyperplastic changes (white bar), adenoma (purple bar), and carcinoma (red bar). N = number of mice used for each genotype (listed below the x-axis).