Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups

Breast Cancer Research

Table 3 Absolute risk^a to develop breast cancer in specific age intervals for cancer-free 40-year-old women by subtype^b and race/ethnicity^c

	Luminal^{b, d}	HER2-positive^{b, d}	Triple-negative^{b, d}	All subtypes
Race/Ethnicity	Percentage (95% CI)	Percentage (95% CI)	Percentage (95% CI)	Percentage (95% CI)
White, age 40
To age 50	0.87 (0.84, 0.90)	0.27 (0.25, 0.29)	0.17 (0.16, 0.19)	1.57 (1.52, 1.61)
To age 70	4.54 (4.45, 4.63)	1.13 (1.09, 1.18)	0.76 (0.72, 0.79)	7.78 (7.67, 7.90)
To end of life	8.00 (7.87, 8.14)	1.74 (1.68, 1.80)	1.19 (1.14, 1.24)	13.6 (13.5, 13.8)
Black, age 40
To age 50	0.59 (0.52, 0.66)	0.31 (0.26, 0.37)	0.34 (0.29, 0.40)	1.51 (1.40, 1.63)
To age 70	2.83 (2.63, 3.03)	1.19 (1.07, 1.33)	1.31 (1.18, 1.45)	6.49 (6.02, 6.80)
To end of life	4.55 (4.35, 4.76)	1.73 (1.55, 1.92)	1.91 (1.73, 2.11)	10.7 (10.3, 11.2)
Hispanic, age 40
To age 50	0.49 (0.46, 0.52)	0.23 (0.21, 0.25)	0.16 (0.14, 0.17)	1.07 (1.03, 1.12)
To age 70	2.49 (2.38, 2.59)	0.94 (0.88, 1.01)	0.65 (0.60, 0.71)	4.99 (4.85, 5.14)
To end of life	4.79 (4.59, 5.00)	1.50 (1.39, 1.61)	0.98 (0.90, 1.07)	8.83 (8.56, 9.11)
Asian, age 40
To age 50	0.71 (0.66, 0.77)	0.34 (0.30, 0.38)	0.10 (0.08, 0.12)	1.41 (1.34, 1.49)
To age 70	2.81 (2.68, 2.95)	1.28 (1.19, 1.37)	0.45 (0.40, 0.51)	5.67 (5.47, 5.87)
To end of life	4.92 (4.66, 5.20)	1.70 (1.66, 1.97)	0.72 (0.63, 0.84)	9.68 (9.31, 10.1)
All races, age 40
To age 50	0.72 (0.70, 0.74)	0.27 (0.26, 0.28)	0.17 (0.16, 0.18)	1.41 (1.38, 1.44)
To age 70	3.72 (3.66, 3.78)	1.12 (1.08, 1.15)	0.73 (0.70, 0.76)	6.83 (6.75, 6.91)
To end of life	6.74 (6.64, 6.84)	1.70 (1.66, 1.75)	1.14 (1.10, 1.18)	12.1 (12.0, 12.3)

^aRisk is conditioned on never having had breast cancer previously. ^bSubtypes were defined by expression of estrogen receptor (ER), progesterone receptor (PR), and Her2/neu (HER2): luminal (ER- or PR-positive or both and HER2-negative), HER2-positive (ER- and PR-positive or -negative and HER2-positive), and triple-negative (ER-negative, PR-negative, and HER2-negative). ^cRacial/ethnic categories are mutually exclusive and include white (non-Hispanic [NH]), black (NH), Hispanic, and Asian (NH, includes Pacific Islander). ^dExcludes 7,737 cases (5,069 whites, 505 blacks, 1,262 Hispanics, and 901 Asians) for whom ER, PR, and/or HER2 were not tested or for whom results were borderline, missing, or unknown; these cases are included in the 'All subtypes' category. CI, confidence interval.

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