Figure 9

Regulation of cell invasion through functional interaction between FASN and HER2 in HER2-overexpressing breast cancer cells. When HRG binds to HER3, HER2 interacts with HER3 and induces tyrosine phosphorylation of HER3. The activated HER2 not only stimulates the PI3K/Akt and MAPK signaling pathways but also induces tyrosine phosphorylation of FASN and upregulation of FASN activity, leading to increased cell invasion. Suppression of FASN indirectly (for example, with lapatinib) or directly (for example, with C75 or si-FASN) inhibits invasion of HER2-overexpressing breast cancer cells.